Y a prominent part in the development of zebrafish larvae (Easter and Nicola, 1996). Consequently, the eyes of a 72-hpf larva are disproportionately significant compared with all the rest from the body than these of an adult zebrafish. In contrast to KD larvae, adult SULT4A1-deficient zebrafish may present with extra important adjustments in diverse pathways for instance circadian rhythm or CREB signaling in neurons (Table 3). To investigate the effects of SULT4A1 knockout in adult zebrafish, a mutant zebrafish line with inheritable deficits in SULT4A1 expression/function is beneath improvement. This study will be the first to determine a cellular course of action whose regulation appears to be associated with SULT4A1 expression. The observation that KD of SULT4A1 expression in zebrafish larvae impacts expression of genes in phototransduction represents the very first achievable function of this conserved orphan SULT. Characterization of visual responses and cone function within the KD larvae could identify the impacted downstream visual signaling pathways.Authorship Contributions Participated in investigation design and style: Crittenden, Kraft, Parant, Falany. Performed experiments: Crittenden, Thomas. Contributed new reagents or analytic tools: Ethen, Wu, Parant, Falany. Performed information analysis: Crittenden, Chen, Kraft, Parant, Falany. Wrote or contributed towards the writing in the manuscript: Crittenden, Chen, Falany.
LETTER Towards the EDITORKorean J Intern Med 2014;29:671-674 http://dx.doi.org/10.3904/kjim.2014.29.five.Immune thrombocytopenic purpura within a patient with renal cell carcinomaEun Ju Cho1, Ha Jung Lee1, Kyung Un Park2, Uk-Yeon Kim3, Hak Jong Lee4 , and Soo Mee BangDepartment of Internal Medicine, Seoul National University College of Medicine, Seoul; Departments of 2Diagnostic Medicine, 3 Pathology, 4Radiology, and five Internal Medicine, Seoul National University Bundang Hospital, Seongnam, KoreaTo the Editor,Thrombocytopenia in cancer patients is triggered by a number of mechanisms: chemotherapy or radiotherapy induce bone marrow hypoplasia, the tumor can infiltrate the bone marrow, or the platelets may be consumed secondary to disseminated intravascular coagulation (DIC) or thrombotic thrombocytopenic purpura.Congo Red The association in between immune thrombocytopenic purpura (ITP) and lymphoid neoplasms, in specific chronic lymphoid leukemia and Hodgkin’s illness, was f irst recognized in 1966 [1] and has been often reported due to the fact then.Vorinostat Having said that, the association with strong tumors is uncommon.PMID:27217159 5 circumstances of renal cell carcinomas (RCCs) related with ITP have been reported in the medical literature [2-4]. In four instances, the thrombocytopenia was refractory to intravenous immunoglobulin or steroids. However, it entirely resolved following curative resection with the underlying RCC. Here, we report the case of a 63-yearold male presenting with extreme ITP and RCC who was effectively treated with danazol and curative nephrectomy. The patient was admitted to our hospital as a result of epistaxis and bleeding in the gums for the duration of the two months prior. He also complained of fever, nightReceived : August 8, 2008 Revised : August 21, 2008 Accepted: August 25, 2008 Correspondence to Soo Mee Bang, M.D. Department of Internal Medicine, Seoul National University Bundang Hospital, 82 Gumi-ro 173beon-gil, Bundanggu, Seongnam 463-707, Korea Tel: +82-31-787-7039 Fax: +82-31-787-4098 E-mail: [email protected], weight-loss, and anorexia. He had a history of hypertension and steady angina. The only medication he was taking was an antih.
