ALK/CD246 Antibody (MM0015-8G33) Summary
| Immunogen |
human TGF RI (ALK1) extra-cellular domain
|
| Specificity |
This recognizes human ALK1.
|
| Isotype |
IgG2
|
| Clonality |
Monoclonal
|
| Host |
Mouse
|
| Gene |
ALK
|
| Purity |
Protein G purified
|
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|
Applications/Dilutions
| Dilutions |
|
| Application Notes |
This antibody recognizes human ALK1 in western blot.
|
Reactivity Notes
This antibody is reactive to human.
Packaging, Storage & Formulations
| Storage |
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
|
| Buffer |
A 0.2 um filtered solution in PBS
|
| Preservative |
No Preservative
|
| Concentration |
LYOPH
|
| Purity |
Protein G purified
|
| Reconstitution Instructions |
Reconstitute to desired concentration.
|
Alternate Names for ALK/CD246 Antibody (MM0015-8G33)
- ALK tyrosine kinase receptor
- ALK
- anaplastic lymphoma kinase (Ki-1)
- Anaplastic lymphoma kinase
- anaplastic lymphoma receptor tyrosine kinase
- CD246 antigen
- CD246
- EC 2.7.10.1
- Ki-1
- NBLST3
- Tcrz
Background
LTK, ALK and Ros have been identified as receptor tyrosine kinases having sequence similarity to the insulin receptor subfamily of kinases. LTK, leukocyte tyrosine kinase, is expressed in murine B lymphocyte precursors and has also been found in forebrain neurons. ALK, anaplastic lymphoma kinase, is normally highly expressed specifically in the nervous system. A truncated form containing the catalytic domian of ALK is expressed as the result of a translocation occuring in many non-Hodgkins lymphomas. The c-Ros gene was originally identified in mutant form as an oncogene. Ros is normally expressed in a small number of epithelial cell types and may play a role in epithelial development.