C1q Antibody [FITC] Summary
| Immunogen |
Human C1q, purified from plasma
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| Specificity |
Recognizes human C1q, a sub-component of the C1 complement component.
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| Isotype |
IgG
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| Clonality |
Polyclonal
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| Host |
Sheep
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| Gene |
C1QA
|
| Purity |
IgG purified
|
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Applications/Dilutions
| Dilutions |
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| Positive Control |
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Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
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| Buffer |
Phosphate buffered saline
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| Preservative |
0.05% Sodium Azide
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| Purity |
IgG purified
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Alternate Names for C1q Antibody [FITC]
- A chain
- complement component 1, q subcomponent, A chain
- complement component 1, q subcomponent, alpha polypeptide
Background
C1q is a sub-component of the first complement component C1, which is formed by the interaction of C1q with the tetramer C1s-C1r-C1r-C1s. C1q is a member of a family of soluble collagen like proteins and is composed of three basic subunits termed A, B and C (27,550, 25,200, 23,800 Da respectively) which associate in the proportion 6 A-B subunits (52, 750 Da) and 3 C-C subunits (47,600 Da), to form whole C1q (459,300 Da). C1q binds to IgG and IgM immune complexes, this activates C1r and C1s, which are also bound to C1q and so initiates the classical pathway of complement activation.