CD3 epsilon Antibody (RIV9)

CD3 epsilon Antibody (RIV9) Summary

Immunogen	Human peripheral lymphocytes
Localization	Cell surface and cytoplasmic
Marker	T-Cell Marker
Specificity	Reacts with five invariable CD3 chains (designated as and ) with molecular weight ranging from 16-28kDa. It is found on all mature T-lymphocytes, NK, T-cells, and some thymocytes. CD3, also known as T3, is a member of the immunoglobulin superfamily that plays a role in antigen recognition, signal transduction, and T cell activation. It is expressed, typically at high levels, on peripheral T cells and majority of T cell neoplasms. Thymocytes express CD3 at different level on the cell surface in the course of differentiation and, in cortical thymus, CD3 is predominantly Intracytoplasmic. This MAb is particularly useful for induction of T cell activation in vitro and in vivo due to its unusual IgG3 isotype.
Isotype	IgG3 Kappa
Clonality	Monoclonal
Host	Mouse
Gene	CD3E
Purity	Protein A purified
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Dilutions	Flow Cytometry 0.5 – 1 ug/million cells in 0.1 ml Immunofluorescence 1 – 2 ug/ml
Application Notes	Hu-chromosome location: 11q23.3 Functional Studies Order Ab without Azide. The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Theoretical MW	20 kDa. Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.