CD46 Antibody (3F1) Summary
| Immunogen |
Recombinant CD46 protein
|
| Specificity |
Monoclonal antibody reacts specifically with 44 kDa protein. Diffuse and duplicated bands can be seen due to the glycosylation of CD46.
|
| Isotype |
IgG1 Kappa
|
| Clonality |
Monoclonal
|
| Host |
Mouse
|
| Gene |
CD46
|
| Purity |
Protein A purified
|
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|
Applications/Dilutions
| Dilutions |
|
Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
|
| Buffer |
PBS
|
| Preservative |
No Preservative
|
| Concentration |
LYOPH
|
| Purity |
Protein A purified
|
| Reconstitution Instructions |
Reconstitute with 0.1 ml distilled water.
|
Alternate Names for CD46 Antibody (3F1)
- AHUS2
- CD46 antigen
- CD46 molecule, complement regulatory protein
- CD46
- MCP
- membrane cofactor protein (CD46, trophoblast-lymphocyte cross-reactive antigen)
- MIC10
- TLXcomplement regulatory protein
- trophoblast leucocyte common antigen
- Trophoblast leukocyte common antigen
- trophoblast-lymphocyte cross-reactive antigen
Background
CD46 (MCP, membrane cofactor protein) is a multifunctional cell surface transmembrane protein that binds and inactivates C3b and C4b complement fragments, regulates T cell-induced inflammatory responses by either inhibiting (CD46-1 isoform) or increasing (CD46-2 isoform) the contact hypersensitivity reaction. CD46 also serves as a receptor for several human pathogens (both bacteria and viruses), and its ligation alteres T lymphocyte polarization toward antigen-presenting cells or target cells, inhibiting lymphocyte function. CD46 is a protector of placental tissue and is also expressed on the inner acrosomal membrane of spermatozoa.