COX4 [p Ser58] Antibody Summary
| Immunogen |
Phosphopeptide corresponding to amino acid residues surrounding the phosphoSer58 of mouse COXIV protein.
|
| Modification |
p Ser58
|
| Marker |
Mitochondria Marker
|
| Specificity |
Specific for the ~17k COXIV-1 protein phosphorylated at Ser58. Immunolabeling is blocked by the phospho-peptide used as antigen but not by the corresponding dephospho-peptide.
|
| Preparation Method |
Prepared from rabbit serum by affinity purification via sequential chromatography on phospho- and dephosphopeptide affinity columns.
|
| Clonality |
Polyclonal
|
| Host |
Rabbit
|
| Gene |
COX4I1
|
| Purity |
Immunogen affinity purified
|
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Applications/Dilutions
| Dilutions |
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Packaging, Storage & Formulations
| Storage |
Store at -20C. Avoid freeze-thaw cycles.
|
| Buffer |
10mM HEPES (pH 7.5), 0.15M NaCl, 0.1 mg/ml BSA and 50% Glycerol
|
| Preservative |
No Preservative
|
| Purity |
Immunogen affinity purified
|
Alternate Names for COX4 [p Ser58] Antibody
- COX IV-1
- COX4
- COX4-1
- COX4COXIV
- COX4I2
- Cytochrome c oxidase polypeptide IV
- cytochrome c oxidase subunit 4 isoform 1, mitochondrial
- cytochrome c oxidase subunit IV isoform 1cytochrome c oxidase subunit IV
- MGC72016
Background
COX, also known as cytochrome c oxidase, has 12 subunits that make up the transmembrane mitochondrial protein. Subunit IV has two isoforms; COXIV-1 and COXIV-2 (Huttermann et al., 2001). COXIV-1 is expressed ubiquitously while COXIV-2 is highly expressed in adult lung and low levels in brain and heart (Huttermann et al., 2001). Phosphorylation of amino acid residue ser58 of the COXIV-1 protein is a PKA-dependent regulation of COX and plays an important role in metabolism and CREB cycle activation (Acin-Perez et al., 2011).