Caspase-13 Antibody Summary
| Immunogen |
Rabbit anti-caspase-13 polyclonal antibody was raised against a peptide corresponding to amino acids 91 to 105 of human caspase-13.
|
| Specificity |
Casp-13 / ERICE
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| Clonality |
Polyclonal
|
| Host |
Rabbit
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| Gene |
CASP13
|
| Purity |
IgG purified
|
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Applications/Dilutions
| Dilutions |
|
| Application Notes |
This polyclonal antibody can be used for detection of AIF by Western blot at 0.5 to 1 ug/ml. HL60 cell lysate can be used as positive control and a 43 kDa band should be detected. It is human, mouse and rat reactive.
|
Reactivity Notes
This antibody is reactive against Human, Mouse, Rat
Packaging, Storage & Formulations
| Storage |
Store at 4C. Do not freeze.
|
| Buffer |
PBS
|
| Preservative |
0.02% Sodium Azide
|
| Purity |
IgG purified
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Alternate Names for Caspase-13 Antibody
- apoptosis-related cysteine protease
- CASP13
- Caspase13
- Caspase-13
- ERICE
Background
Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death is finally caused by members of the caspase family of proteases and caspase activated DNases. A novel member in the caspase family was recently identified and designated ERICE (for Evolutionarily Related Interleukin-1 beta Converting Enzyme) and caspase-13 (1). Caspase-13 belongs to the ICE subfamily of caspases. Overexpression of caspase-13 induces apoptosis. Caspase-13 was activated by caspase-8, which is a key enzyme in death receptor induced apoptosis. Caspase-13 is expressed in a variety of human tissues and cell lines (1).