EGF R/ErbB1 Antibody (SPM622) [DyLight 755] Summary
| Immunogen |
Human EGFR purified from A431 cells
|
| Localization |
Cell surface
|
| Specificity |
This MAb recognizes a protein of 170kDa, identified as EGFR. EGFR is type I receptor tyrosine kinase with sequence homology to erbB-1, -2, -3 -4 or HER-1, -2, -3 -4. It binds to Epidermal Growth Factor (EGF), Transforming Growth Factor-a (TGF-a), Heparin-binding EGF (HB-EGF), amphiregulin, Beta cellulin and epiregulin. EGFR is overexpressed in tumors of breast, brain, bladder, lung, gastric, head & neck, esophagus, cervix, vulva, ovary, and endometrium. It is predominantly present in squamous cell carcinomas.
|
| Isotype |
IgG1 Kappa
|
| Clonality |
Monoclonal
|
| Host |
Mouse
|
| Gene |
EGFR
|
| Purity |
Protein A or G purified
|
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|
Applications/Dilutions
| Dilutions |
|
| Application Notes |
Optimal dilution of this antibody shomld be experimentally determined.
|
Packaging, Storage & Formulations
| Storage |
Store at 4C in the dark.
|
| Buffer |
50mM Sodium Borate
|
| Preservative |
0.05% Sodium Azide
|
| Purity |
Protein A or G purified
|
Notes
Dylight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.
Alternate Names for EGF R/ErbB1 Antibody (SPM622) [DyLight 755]
- avian erythroblastic leukemia viral (v-erb-b) oncogene homolog
- cell growth inhibiting protein 40
- cell proliferation-inducing protein 61
- EC 2.7.10
- EC 2.7.10.1
- EGF R
- EGFR
- epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b)oncogene homolog)
- epidermal growth factor receptor
- ErbB
- ErbB1
- ERBB1PIG61
- HER1
- HER-1
- mENA
- Proto-oncogene c-ErbB-1
- Receptor tyrosine-protein kinase erbB-1