Product: PFI-2 (hydrochloride)
FEM1B Antibody Summary
| Immunogen |
Rabbit anti-F1Aalpha polyclonal antibody was raised against a peptide (DINYQDQIPRTLEE) corresponding to amino acids 609 to 622 of human F1Aalpha (1). This sequence is identical to the corresponding sequence of mouse FEM1beta (2).
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| Specificity |
F1Aa
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| Clonality |
Polyclonal
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| Host |
Rabbit
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| Gene |
FEM1B
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| Purity |
IgG purified
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Applications/Dilutions
| Dilutions |
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| Application Notes |
This polyclonal antibody can be used for detection of F1Aa by Western blot at 0.5 – 1 ug/ml. Mouse liver tissue lysate can be used as positive control and an approximately 70 kDa band can be detected. It is human, mouse, and rat reactive.
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Reactivity Notes
This antibody is reactive against Human, Mouse, Rat
Packaging, Storage & Formulations
| Storage |
Store at 4C. Do not freeze.
|
| Buffer |
PBS
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| Preservative |
0.02% Sodium Azide
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| Purity |
IgG purified
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Alternate Names for FEM1B Antibody
- DKFZp451E0710
- F1AA
- F1A-alpha
- FEM-1 (C.elegans) homolog b
- fem-1 homolog b (C. elegans)
- FEM1b
- FEM1-beta
- FEM-1-like death receptor binding protein
- Fem-1-like death receptor-binding protein alpha
- Fem-1-like in apoptotic pathway protein alpha
- FIAA
- KIAA0396
- protein fem-1 homolog B
Background
Fas and tumor necrosis factor receptor 1 (TNFR1) are two prototype members in the death receptor family. A novel protein that associates with the intracellular domains of Fas and TNFR1 was recently identified and designated F1Aalpha and FEM1beta (1,2). F1Aalpha/FEM1beta is the homologue of C. elegans sex determining protein FEM-1 (1,2). FEM-1/F1Aalpha is cleaved by CED-3 and caspase (3). FEM-1/F1Aalpha associates with CED-4 and its mammalian homologue Apaf-1 (3). Overexpression of F1Aalpha induces apoptosis. F1Aalpha is therefore a novel member of the death receptor associated protein that mediates apoptosis. F1Aalpha is expressed in a variety of human and mouse tissues (1,2)