Product: Cevimeline (hydrochloride)
G2A/GPR132 Antibody Summary
| Immunogen |
Synthetic 18 amino acid peptide from 3rd extracellular domain of human GPR132 / G2A.
|
| Localization |
Cell Membrane
|
| Specificity |
Human GPR132 / G2A. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except PRDM4 (61%).
|
| Predicted Species |
Monkey (94%). Backed by our 100% Guarantee.
|
| Clonality |
Polyclonal
|
| Host |
Rabbit
|
| Gene |
GPR132
|
| Purity |
Immunogen affinity purified
|
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|
Applications/Dilutions
| Dilutions |
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Reactivity Notes
Predicted cross-reactivity based on sequence identity: Gibbon (100%), Gorilla (100%), Marmost (83%).
Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
|
| Buffer |
PBS
|
| Preservative |
0.1% Sodium Azide
|
| Concentration |
1.0 mg/ml
|
| Purity |
Immunogen affinity purified
|
Alternate Names for G2A/GPR132 Antibody
- G protein-coupled receptor 132
- G2 accumulation protein
- G2A
- G2AG protein-coupled receptor G2A
- GPR132
- MGC99642
- probable G-protein coupled receptor 132
Background
G2A belongs to the Lysophospholipid/Lysosphingolipid Receptor family and is an anti-proliferative cell cycle regulator that plays a critical role in controlling peripheral lymphocyte homeostasis. Loss of G2A expression leads to the development of a late-onset autoimmune syndrome (Le et al, 2001). Lysophosphatidylcholine (LPC) is the activating ligand for G2A. G2A is expressed in lymphoid tissues. ESTs have been isolated from normal human primary B-cell from tonsil, leukocyte, colon, lung, and pancreas/spleen, melanocyte/uterus/fetal heart libraries and from a human bone marrow cancer library.