GEMIN2 Overexpression Lysate (Denatured) Summary
| Description |
Pasmid: pCMV-SIP1 full-length
|
| Gene |
GEMIN2
|
Packaging, Storage & Formulations
| Storage |
Store at -80C. Avoid freeze-thaw cycles.
|
| Buffer |
Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, and 0.01% Bromophenol blue).
|
Lysate Details for GEMIN2
| Type |
Overexpression
|
| Protein State |
Denatured
|
Notes
Quality control test: Transient overexpression cell lysate was tested with Anti-SIP1 antibody by Western Blots.
This product is produced by and distributed for Abnova, a company based in Taiwan.
Alternate Names for GEMIN2 Overexpression Lysate (Denatured)
- Component of gems 2
- Gemin-2
- GEMIN2survival of motor neuron protein-interacting protein 1
- SIP1-delta
- SMN interacting protein 1-delta
- SMN-interacting protein 1
- survival of motor neuron protein interacting protein 1
Background
This gene encodes one of the proteins found in the SMN complex, which consists of the suvival of motor neuron protein and several gemin proteins. The SMN complex is localized to a subnuclear compartment called gems (gemini of coiled bodies) and is required for assembly of spliceosomal snRNPs and for pre-mRNA splicing. This protein interacts directly with the survival of motor neuron protein and it is required for formation of the SMN complex. A knockout mouse targeting the mouse homolog of this gene exhibited disrupted snRNP assembly and motor neuron degeneration.