Product: Monohydroxy Netupitant D6
GFR alpha-1/GDNF R alpha-1 Antibody Summary
| Immunogen |
Rabbit anti- GFRalpha-1 polyclonal antibody was raised against a peptide corresponding to amino acids 369 to 382 of human GFRalpha-1 (1).
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| Specificity |
GFRa-1 / GDNFRa
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| Clonality |
Polyclonal
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| Host |
Rabbit
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| Gene |
GFRA1
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| Purity |
IgG purified
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Applications/Dilutions
| Dilutions |
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| Application Notes |
This polyclonal antibody can be used for detection of GFRa-1 by Western blot. The amino acid sequence of immunogenic peptide is identical to those of mouse and rat and the antibody recognizes GFRa-1 from human, mouse and rat origins.
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Reactivity Notes
This antibody is reactive against Human, Mouse, Rat
Packaging, Storage & Formulations
| Storage |
Store at -20C. Avoid freeze-thaw cycles.
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| Buffer |
PBS
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| Preservative |
0.02% Sodium Azide
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| Concentration |
0.25 mg/ml
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| Purity |
IgG purified
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Alternate Names for GFR alpha-1/GDNF R alpha-1 Antibody
- DKFZp313E1012
- DKFZp686J0156
- GDNF family receptor alpha 1
- GDNF family receptor alpha-1
- GDNF R alpha-1
- GDNF receptor alpha-1
- GDNFRAGFR-ALPHA-1
- GDNFR-alpha-1
- GDNFRMGC23045
- GFR alpha1
- GFR alpha-1
- GFRA1
- GFRa-1
- GFR-alpha-1
- Glial cell line-derived neurotrophic factor receptor alpha
- GPI-linked anchor protein
- PI-linked cell-surface accessory protein
- RET ligand 1
- RET1L
- RETL1FLJ10561
- TGF-beta related neurotrophic factor receptor 1
- TGF-beta-related neurotrophic factor receptor 1
- TRNR1FLJ31546
Background
Glial cell line-derived neurotrophic factor (GDNF) is a potent survival factor for central and peripheral neurons and is essential for the development of kidneys and the enteric nerves system. Physiological responses to GDNF require the presence of a novel glycosylphosphadidylinositol linked protein GDNFRalpha, which is a cell surface receptor for GDNF (1,2). The cDNAs encoding GDNFRalpha from human, rat, chicken and mouse have been cloned recently (1-5). GDNFRalpha was also termed Ret ligand 1 (RETL1) or TGF-beta-related neurotrophic factor receptor 1 (TrnR1) and nominated as GFRalpha-1 recently (5-7). GFRalpha-1 binds GDNF specifically and mediates activation of the Ret protein tyrosine kinase (PTK). Thus, GDNF, GFRalpha and the Ret PTK form a complex to transduce GDNF signal and to mediate GDNF function.