GRIM19 Antibody Summary
| Immunogen |
Synthetic peptide to human GRIM-19 (QAETDRRTLQMLRE).
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| Specificity |
Reacts with the human and mouse GRIM-19 protein.
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| Clonality |
Polyclonal
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| Host |
Rabbit
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| Gene |
NDUFA13
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| Purity |
Immunogen affinity purified
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Applications/Dilutions
| Dilutions |
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| Application Notes |
Western blot- Use at 1:500 to 1:1,000 dilution. However, the investigator should determine the optimal dilution for a specific application such as immunohistochemistry.
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| Positive Control |
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Reactivity Notes
Human.
Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
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| Buffer |
PBS
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| Preservative |
0.02% Sodium Azide
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| Concentration |
1 mg/ml
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| Purity |
Immunogen affinity purified
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Alternate Names for GRIM19 Antibody
- B16.6
- CDA016
- Cell death regulatory protein GRIM-19
- cell death-regulatory protein GRIM19
- CI-B16.6
- complex I B16.6 subunit
- Complex I-B16.6
- FLJ58045
- FLJ59191
- Gene associated with retinoic and IFN-induced mortality 19 protein
- Gene associated with retinoic and interferon-induced mortality 19 protein
- GRIM-19CGI-39
- GRIM19NADH-ubiquinone oxidoreductase B16.6 subunit
- NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13
Background
A novel gene, Genes associated with Retinoid-IFN-induced Mortality (GRIM) GRIM-19 gene was identified. Antisense expression of GRIM-19 confers a strong resistance against IFN/RA-induced death by reducing the intracellular levels of GRIM-19 protein. Overexpression of GRIM-19 enhances cell death in response to IFN/RA. GRIM-19 is primarily a nuclear protein whose expression is induced by the IFN/RA combination. These data indicate that GRIM-19 is a novel cell death-regulatory molecule.