HIF-1 alpha Antibody (OZ12) Summary
| Immunogen |
BALB/C mice were injected with hHIF-1 alpha (aa 530-826) protein.
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| Localization |
Cytoplasmic in normoxia, nuclear translocation in response to hypoxia.
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| Isotype |
IgG1 Kappa
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| Clonality |
Monoclonal
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| Host |
Mouse
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| Gene |
HIF1A
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| Purity |
Protein A or G purified
|
| Innovators Reward |
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|
Applications/Dilutions
| Dilutions |
|
|
| Theoretical MW |
93 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. |
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| Publications |
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Packaging, Storage & Formulations
| Storage |
Store at 4C. Do not freeze.
|
| Buffer |
No buffer
|
| Preservative |
No Preservative
|
| Purity |
Protein A or G purified
|
Alternate Names for HIF-1 alpha Antibody (OZ12)
- ARNT-interacting protein
- Basic-helix-loop-helix-PAS protein MOP1
- BHLHE78
- Class E basic helix-loop-helix protein 78
- HIF 1A
- HIF1 alpha
- HIF-1 alpha
- HIF1A
- HIF-1a
- HIF-1-alpha
- HIF1-alpha
- hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcriptionfactor)
- hypoxia-inducible factor 1-alpha
- Member of PAS protein 1
- member of PAS superfamily 1
- MOP1HIF1-ALPHA
- PAS domain-containing protein 8
- PASD8alpha subunit (basic helix-loop-helix transcriptionfactor)
Background
Oxygen availability plays a major role in the regulation of expression of many different genes including erythropoietin, nitric oxide synthase (NOS), heme oxygenase 1 (HO-1), glucose transporters and vascular growth factors necessary for the maintenance of homeostasis in hypoxic conditions. Hypoxia-inducible factor 1 alpha (HIF1 alpha) has been identified as a bHLH-PAS family member that is instrumental in the oxygen-dependent regulation of these genes. HIF1 alpha rapidly accumulates in the nucleus upon exposure to hypoxic conditions where it heterodimerises with the aryl hydrocarbon nuclear receptor translocator ARNT (also referred to as HIF1 beta). Heterodimerisation promotes efficient DNA binding.