HSD11B2 Antibody Summary
| Immunogen |
Synthetic peptide corresponding to aa 25-40 (R25SDLRLGRPLLAALAL40) of human 11 beta-HSD2.
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| Specificity |
Recognizes human, mouse and rat 11 beta-HSD2. Other species have not been tested.
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| Predicted Species |
Porcine (94%), Bat (94%), Primate (94%), Bovine (94%), Monkey (100%), Sheep (94%), Rabbit (94%). Backed by our 100% Guarantee.
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| Isotype |
IgG
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| Clonality |
Polyclonal
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| Host |
Rabbit
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| Gene |
HSD11B2
|
| Purity |
Immunogen affinity purified
|
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|
Applications/Dilutions
| Dilutions |
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Reactivity Notes
Predicted cross-reactivity based on sequence identity: Gorilla (100%), Gibbon (100%), Marmoset (94%), Elephant (88%), Equine (88%).
Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
|
| Buffer |
TBS
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| Preservative |
No Preservative
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| Concentration |
1.0 mg/ml
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| Purity |
Immunogen affinity purified
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Alternate Names for HSD11B2 Antibody
- 11 betaHSD2
- 11 beta-HSD2
- AME
- corticosteroid 11-beta-dehydrogenase isozyme 2,11-beta-HSD2
- EC 1.1.1
- EC 1.1.1.-
- HSD11B2
- HSD11KAME1
- HSD2,11-DH2
- hydroxysteroid (11-beta) dehydrogenase 2
- NAD-dependent 11-beta-hydroxysteroid dehydrogenase
- SDR9C3
- short chain dehydrogenase/reductase family 9C member 3,11-beta-hydroxysteroid dehydrogenase type 2
Background
HSD11B2 catalyzes the conversion of cortisol to the inactive metabolite cortisone. The protein modulates intracellular glucocorticoid levels, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids. Defects in HSD11B2 are the cause of apparent mineralocorticoid excess (AME). AME is a potentially fatal disease characterized by severe juvenile low-renin hypertension, sodium retention, hypokalemia and low levels of aldosterone. It often leads to nephrocalcinosis.