ILT5/CD85a/LILRB3 Antibody (4F9) Summary
| Immunogen |
Monocyte derived dendritic cells
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| Specificity |
NB100-64329 is specific for human CD85a (leucocyte immunoglobulin-like receptor, subfamily B, member 3/ LILRB3), also known as ILT-5, expressed by monocytes, dendritic cells, macrophages, subpopulation of T lymphocytes, B cells and at high levels on plasma cells. CD85a is a 631 amino acid type I transmembrane glycoprotein, which contains four immunoreceptor tyrosine-based inhibition motif (ITIM) sequences within a long cytoplasmic tail. Phosphorylation of the tyrosine residues within ITIMs is known to enable the binding and activation of protein tyrosine phosphatases, which act as cell signalling modulators and inhibitors of cell activation.
|
| Isotype |
IgG1
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| Clonality |
Monoclonal
|
| Host |
Mouse
|
| Gene |
LILRB3
|
| Purity |
Protein G purified
|
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Applications/Dilutions
| Dilutions |
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| Positive Control |
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Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
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| Buffer |
Phosphate buffered saline
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| Preservative |
0.09% Sodium Azide
|
| Concentration |
1.0 mg/ml
|
| Purity |
Protein G purified
|
Alternate Names for ILT5/CD85a/LILRB3 Antibody (4F9)
- CD85 antigen-like family member A
- CD85a antigen
- CD85a
- HL9Immunoglobulin-like transcript 5
- ILT5
- ILT-5
- ILT5CD85a
- Leukocyte immunoglobulin-like receptor 3
- leukocyte immunoglobulin-like receptor subfamily B member 3
- leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains)
- LILRB3
- LIR3
- LIR3CD85A
- LIR-3MGC138403
- member 3
- Monocyte inhibitory receptor HL9
- PIRB
Background
LILRB3 is a 631 amino acid type I transmembrane glycoprotein, which contains four immunoreceptor tyrosine-based inhibition motif (ITIM) sequences within a long cytoplasmic tail. Phosphorylation of the tyrosine residues within ITIMs is known to enable the binding and activation of protein tyrosine phosphatases, which act as cell signaling modulators and inhibitors of cell activation. LILRB3 may act as receptor for class I MHC antigens.