Product: Autotaxin modulator 1
MMP-10 Antibody (MM0019-9G10) Summary
| Immunogen |
This antibody was produced from a hybridoma (mouse myeloma fused withspleen cells from a mouse immunized with purified human recombinant MMP-10).
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| Specificity |
MMP10 (MM0019-9G10)
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| Isotype |
IgG2
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| Clonality |
Monoclonal
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| Host |
Mouse
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| Gene |
MMP10
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| Purity |
Protein G purified
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Applications/Dilutions
| Dilutions |
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| Application Notes |
This antibody recognizes human MMP-10 in western blot without cross reactivity other human MMPs.
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Reactivity Notes
This antibody is reactive against human. Not yet tested in other species.
Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
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| Buffer |
A 0.2 um filtered solution in PBS
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| Preservative |
No Preservative
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| Concentration |
LYOPH
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| Purity |
Protein G purified
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| Reconstitution Instructions |
Reconstitute with 0.5 ml sterilized PBS to a final concentration of 0.2 mg/ml.
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Alternate Names for MMP-10 Antibody (MM0019-9G10)
- EC 3.4.24
- EC 3.4.24.22
- matrix metallopeptidase 10 (stromelysin 2)
- matrix metalloprotease 10
- matrix metalloproteinase 10 (stromelysin 2)
- Matrix metalloproteinase-10
- MMP10
- MMP-10
- SL-2
- STMY2stromelysin-2
- Stromelysin 2
- transin 2
- transin-2
Background
Proteins of the matrix metalloproteinase (MMP) family are zinc containing proteolytic enzymes involved in the breakdown of the extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling. They also play an important role in apoptosis, tumor cell growth, invasion, metastasis, as well as in angiogenesis and wound healing. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. Most of the MMPs contain a common domain structure, which include a signal sequence, a propeptide, a catalytic domain and a hemopexin-like (Hpx) domain. MMP10 degrades proteoglycans, gelatins of type I, III, IV, and V; weakly collagens III, IV, and V. and fibronectin. It activates procollagenase. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.