MMP-13 Antibody (MM0019-12E10) Summary
| Immunogen |
This antibody was produced from a hybridoma (mouse myeloma fused withspleen cells from a mouse immunized with purified human recombinant human MMP-13).
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| Specificity |
MMP13 without cross-reactivity with other human MMPs.
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| Isotype |
IgG1
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| Clonality |
Monoclonal
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| Host |
Mouse
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| Gene |
MMP13
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| Purity |
Protein G purified
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Applications/Dilutions
| Dilutions |
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Reactivity Notes
Human.
Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
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| Buffer |
A 0.2 um filtered solution in PBS
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| Preservative |
No Preservative
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| Concentration |
LYOPH
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| Purity |
Protein G purified
|
| Reconstitution Instructions |
Reconstitute with 0.5 ml sterilized PBS to a final concentration of 0.2 mg/ml.
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Alternate Names for MMP-13 Antibody (MM0019-12E10)
- CLG 3
- CLG3EC 3.4.24
- collagenase 3
- EC 3.4.24.-
- EC 3.4.24.22
- EC 3.4.24.24
- EC 3.4.24.35
- EC 3.4.24.65
- EC 3.4.24.7
- MANDP1
- matrix metallopeptidase 13 (collagenase 3)
- matrix metalloproteinase 13 (collagenase 3)
- Matrix metalloproteinase-13
- MMP13
- MMP-13
Background
Collagenase 3 (MMP13) is a secreted 452 residue protein which is released from cells as aninactive zymogen and activated extracellularly by removal of its propeptide. MMP13 was first identified in tumor cells but has since been found in synoviocytes and normal fibroblasts stimulated by IL6 or a combination of TNF alpha and IL1. Under normal conditions, MMP13 is expressed during embryogenesis (fetal bone development) and is present only at very low levels in adult tissue. However, this enzyme is reported to be involved in the development and metastasis of breast and lung carcinomas, chondrosarcomas and osteosarcomas, head and neck carcinomas and some forms of skin cancer. Additionally, this enzyme plays an important role in degenerative bone diseases including osteoarthritis and rheumatoid arthritis. In rodents, MMP13 is thought to fill the role of MMP1, which they appear to lack.