MS4A1/CD20 Antibody (IGEL/1497R) [Alexa Fluor® 488] Summary
| Immunogen |
Recombinant human MS4A1 protein fragment
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| Localization |
Predominantly cell surface with some cytoplasmic
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| Marker |
B-Cell Marker
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| Specificity |
Recognizes a protein of 30-33kDa, which is identified as CD20. It is a non-Ig differentiation antigen of B-cells and its expression is restricted to normal and neoplastic B-cells, being absent from all other leukocytes and tissues. CD20 is expressed by pre B-cells and persists during all stages of B-cell maturation but is lost upon terminal differentiation into plasma cells. This MAb can be used for immunophenotyping of leukemia and malignant cells, B lymphocyte detection in peripheral blood and B cell localization in tissues. It reacts with the majority of B-cells present in peripheral blood and lymphoid tissues and their derived lymphomas. In lymphoid tissue, germinal center blasts and B-immunoblasts are particularly reactive. It is a reliable antibody for ascribing a B-cell phenotype in known lymphoid tissues. Rarely, CD20-positive T-cell lymphomas have been reported. Reactivity has also been noted with Reed-Sternberg cells in cases of Hodgkins disease, particularly of lymphocyte predominant type.
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| Isotype |
IgG
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| Clonality |
Monoclonal
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| Host |
Rabbit
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| Gene |
MS4A1
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| Purity |
Protein A purified
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Applications/Dilutions
| Dilutions |
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| Application Notes |
Optimal dilution of this antibody should be experimentally determined.
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Packaging, Storage & Formulations
| Storage |
Store at 4C in the dark.
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| Buffer |
50mM Sodium Borate
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| Preservative |
0.05% Sodium Azide
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| Purity |
Protein A purified
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Notes
This product is provided under an intellectual property license from Life Technologies Corporation. The purchase of this product conveys to the buyer the non-transferable right to use the purchased product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components, or any materials made using the product or its components, in any activity to generate revenue, which may include, but is not limited to use of the product or its components: (i) in manufacturing; (ii) to provide a service, information, or data in return for payment; (iii) for therapeutic, diagnostic or prophylactic purposes; or (iv) for resale, regardless of whether they are resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5791 Van Allen Way, Carlsbad, CA 92008 USA or [email protected].
Alternate Names for MS4A1/CD20 Antibody (IGEL/1497R) [Alexa Fluor® 488]
- B1
- B-lymphocyte antigen CD20
- B-lymphocyte cell-surface antigen B1
- B-lymphocyte surface antigen B1
- Bp35
- Bp35MGC3969
- CD20 antigen
- CD20 receptor
- CD20
- CD20S7
- CVID5
- LEU-16
- Leukocyte surface antigen Leu-16
- Ly-44
- Membrane-spanning 4-domains subfamily A member 1
- membrane-spanning 4-domains, subfamily A, member 1
- MS4A1
- MS4A2
- S7