Mucin 5AC Antibody (58M1)

M1 mucin preparation from the fluid of an ovarian mucinous cyst belonging to an O Le(a-b) patient.

Cytoplasmic

This MAb recognizes the peptide core of gastric mucin M1 (recently identified as Mucin 5AC). Its epitope is destroyed by beta-mercaptoethanol but not by periodate treatment. This mucin is present in primary ovarian mucinous cancer but usually absent in colorectal adenocarcinoma, thus showing an expression pattern opposite to MUC2. Together with a panel of antibodies, Anti-MUC5AC may be useful for differential identification of primary mucinous ovarian tumors from colon adenocarcinoma metastatic to the ovary. MUC5AC antibodies may also be useful for identification of intestinal metaplasia as well as in the identification of pancreatic carcinoma and pre-cancerous changes vs. normal pancreas.

IgG1 Kappa

Monoclonal

Mouse

MUC5AC

Protein A or G purified

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Hu-chromosome location: 11p15.5
Molecular weight of antigen: >1,000kDa
Immunohistochemistry-Paraffin 1 – 2 ug/ml for 30 minutes at RT; Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10 – 20 min followed by cooling at RT for 20 minutes.