NKX2.2 Antibody (NX2/1422)

Recombinant human NKX2.2 protein fragment

Nuclear

Neuroendocrine & Ewing’s Sarcoma Marker

Expression of NKX2.2 has been found in neuroendocrine tumors of the gut, making it a potential marker for the study of gastrointestinal neuroendocrine tumors. More recently, NKX2.2 protein was identified as a target of EWS-FLI-1, the fusion protein specific to Ewing sarcoma, and was shown to be differentially upregulated in Ewing sarcoma on the basis of array-based gene expression analysis. It acts as a valuable marker for Ewing sarcoma, with a sensitivity of 93% and a specificity of 89%, and aids in the differential diagnosis of small round cell tumors.

IgG

Monoclonal

Rabbit

NKX2-2

Protein A or G purified

Test in a species/application not listed above to receive a full credit towards a future purchase.

Hu Chromosome Location: 20p11.22
Mol. Weight of Antigen: 40-50kDa
Immunohistology (Formalin-fixed) (1-2ug/ml for 30 minutes at RT) (Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)