NMDA R, NR2C Subunit [p Ser1096] Antibody Summary
| Immunogen |
Synthetic phospho-peptide surrounding the phospho Ser1096 of the NR2C-subunit of rat NMDA receptor.
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| Modification |
p Ser1096
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| Specificity |
Specific for the ~140k NR2C subunit of the NMDA receptor phosphorylated at Ser1096. Immunolabeling is blocked by preadsorption of antibody with the phospho-peptide that was used to generate the antibody but not by the corresponding dephospho-peptide.
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| Preparation Method |
Prepared from rabbit serum by affinity purification via sequential chromatography on phospho- and dephosphopeptide affinity columns.
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| Predicted Species |
Human (100%), Canine (100%), Bovine (100%), Primate (100%). Backed by our 100% Guarantee.
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| Clonality |
Polyclonal
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| Host |
Rabbit
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| Gene |
GRIN2C
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| Purity |
Immunogen affinity purified
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Applications/Dilutions
| Dilutions |
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Packaging, Storage & Formulations
| Storage |
Store at -20C. Avoid freeze-thaw cycles.
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| Buffer |
10mM HEPES (pH 7.5), 0.15M NaCl, 0.1 mg/ml BSA and 50% Glycerol
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| Preservative |
No Preservative
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| Purity |
Immunogen affinity purified
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Alternate Names for NMDA R, NR2C Subunit [p Ser1096] Antibody
- glutamate [NMDA] receptor subunit epsilon-3
- glutamate receptor, ionotropic, N-methyl D-aspartate 2C
- GRIN2C
- NMDA R, NR2C Subunit
- NMDAR2C
- NMDAR2CNR2C
- N-methyl D-aspartate receptor subtype 2C
- N-methyl-D-aspartate receptor subunit 2C
- NR2C
Background
The ion channels activated by glutamate that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR). The NMDAR plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimers, epilepsy and ischemic neuronal cell death (Grosshans et al., 2002; Wenthold et al., 2003; Carroll and Zukin, 2002). The NMDA receptor is also one of the principal molecular targets for alcohol in the CNS (Lovinger et al., 1989; Alvestad et al., 2003; Snell et al., 1996). The NMDAR is also potentiated by protein phosphorylation (Lu et al., 1999). The NR2C subunit of the receptor is thought to influence the NMDAR conductance level (Ebralidze et al., 1996). Phosphorylation of Ser1096 by PKB on NR2C has been recently demonstrated to regulate NMDA receptor binding to 14-3-3 (Chen & Roche 2009).