Nicotinic Acetylcholine R alpha 3/CHRNA3 Antibody Summary
| Immunogen |
This CHRNA3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 25-52 amino acids from the N-terminal region of human CHRNA3.
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| Clonality |
Polyclonal
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| Host |
Rabbit
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| Gene |
CHRNA3
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| Purity |
Protein A purified
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Applications/Dilutions
| Dilutions |
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Reactivity Notes
Reacts with Human. Predicted to react with Bovine.
Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
|
| Buffer |
PBS
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| Preservative |
0.09% Sodium Azide
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| Purity |
Protein A purified
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Alternate Names for Nicotinic Acetylcholine R alpha 3/CHRNA3 Antibody
- cholinergic receptor, nicotinic, alpha 3
- cholinergic receptor, nicotinic, alpha polypeptide 3
- CHRNA3
- LNCR2
- MGC104879
- NACHRA3
- neuronal acetylcholine receptor subunit alpha-3
- neuronal nicotinic acetylcholine receptor, alpha3 subunit
- Nicotinic Acetylcholine R alpha 3
- Nicotinic Acetylcholine Ra3
- PAOD2
Background
CHRNA3 locus encodes a member of the nicotinic acetylcholine receptor family of proteins. Members of this family of proteins form pentameric complexes comprised of both alpha and beta subunits. This locus encodes an alpha-type subunit, as it contains characteristic adjacent cysteine residues. The encoded protein is a ligand-gated ion channel that likely plays a role in neurotransmission. Polymorphisms in this gene have been associated with an increased risk of smoking initiation and an increased susceptibility to lung cancer. Alternatively spliced transcript variants have been described.