Rotavirus Antibody Summary
| Immunogen |
Five serotypes of group A Rotavirus strains Wa (serotype I), DS-1 (serotype II), Ito (III), HOCHI (IV) and 69M (VIII).
|
| Specificity |
NB100-64396 recognizes human rotavirus serotypes I, II, III, IV and VIII. Rotaviruses are RNA viruses from the family Reoviridae that are the the most common cause of gastroenteritis in infants. The nucleic acid is contained in a triple layered protein capsid consisting of outer capsid proteins, VP4 and VP7. Immunization was performed with live Rotavirus serotypes to avoid the risk of surface protein damage (VP7 and VP4).
|
| Isotype |
IgG
|
| Clonality |
Polyclonal
|
| Host |
Sheep
|
| Purity |
Protein G purified
|
| Innovators Reward |
Test in a species/application not listed above to receive a full credit towards a future purchase.
Learn about the Innovators Reward
|
Applications/Dilutions
| Dilutions |
|
Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
|
| Buffer |
PBS (pH 7.2)
|
| Preservative |
0.09% Sodium Azide
|
| Concentration |
5 mg/ml
|
| Purity |
Protein G purified
|
Alternate Names for Rotavirus Antibody
- Major inner capsid protein VP6
- VP6
Background
Rotaviruses, members of the family Reoviridae, are a major cause of diarrhoea in young mammals. Rotavirus infections also result in economic losses in agriculture due to diarrhoea in calf, pig, sheep, and poultry rearing. Diarrhoea (or scours) due to the rotavirus Nebraska Calf Diarrhea Virus can affect calves up to 30 days of age or older. Diarrhoea begins 2 to 3 days after exposure. Diagnosis is by history, lesions (ulcers on the tongue, lips, and mouth) and diagnostic laboratory tests. Mortality rates may be as high as 50 percent, depending on the secondary bacteria present. Human rotaviruses, the major aetiological agents of severe infantile diarrhoea worldwide, display surprisingly diverse and complex serotypic specificities. Rotaviruses are 70 nm, non enveloped viruses comprised of a triple layered protein capsid; Outer capsid proteins are VP4 and VP7, Inner capsid -VP6 and Core -VP2. The immunity acquired from exposure to rotavirus appears to be type specific following initial infection; therefore, multiple serotypes of rotavirus mean multiple opportunities for infection. The combination of animal reservoirs for the virus and rotavirus gene reassortment provides the potential for dramatic genetic shifts (similar to influenza virus) which could give rise to altered host ranges and viral virulence.