TR alpha/NR1A1/Thyroid Hormone Receptor alpha Antibody (1330) Summary
| Immunogen |
Peptide corresponding to amino acid residues from the N-terminal region of human thyroid hormone receptor, alpha 2-isotype.
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| Specificity |
Specific for the ~58k TR-alpha 2 protein.
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| Predicted Species |
Mouse (100%), Bovine (100%), Primate (100%). Backed by our 100% Guarantee.
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| Isotype |
IgG1
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| Clonality |
Monoclonal
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| Host |
Mouse
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| Gene |
THRA
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| Purity |
Protein G purified
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| Innovators Reward |
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|
Applications/Dilutions
| Dilutions |
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Reactivity Notes
It is anticipated that the antibody will react with bovine, mouse and non-human primates based on the fact that these species have 100% homology with the amino acid sequence used as antigen.
Packaging, Storage & Formulations
| Storage |
Store at -20C. Avoid freeze-thaw cycles.
|
| Buffer |
10mM HEPES (pH 7.5), 0.15M NaCl, 0.1 mg/ml BSA and 50% Glycerol
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| Preservative |
No Preservative
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| Purity |
Protein G purified
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Alternate Names for TR alpha/NR1A1/Thyroid Hormone Receptor alpha Antibody (1330)
- AR7
- c-ERBA-1
- c-erbA-alpha
- EAR7
- EAR-7
- EAR-7.1/EAR-7.2
- ERBA
- ERBA1thyroid hormone receptor, alpha (avian erythroblastic leukemia viral (v-erb-a)oncogene homolog)
- ERBA-related 7
- MGC000261
- MGC43240
- NR1A 1
- NR1A1
- NR1A1THRA3
- Nuclear receptor subfamily 1 group A member 1
- THRA
- THRA1ERB-T-1
- THRA2
- thyroid hormone receptor alpha
- thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a)oncogene homolog, avian)
- TR alpha
- triiodothyronine receptor
- v-ErbA1
- V-erbA-related protein 7
Background
Thyroid hormones are essential for development of the central nervous system and deficits in these hormones during development affects such cognitive functions as learning and memory (Ambrogini et al., 2005; Chan and Kilby, 2000). Thyroid hormones exert their physiological role mainly through binding to specific nuclear receptors including the predominant isoforms of thyroid hormone receptors, TRalpha1, TRalpha2, TRbeta1 and TRbeta2. TRalpha1, TRbeta1 and TRbeta2 bind T3 with high affinity and also bind to thyroid hormone response elements (TREs) on chromatin to regulate the transcriptional processes in several target tissues, including adult rat brain (Constantinou et al., 2005).