Troponin I Type 3 (cardiac) [p Ser43] Antibody Summary
| Immunogen |
Phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser43 of mouse troponin I, cardiac (cTnI).
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| Modification |
p Ser43
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| Specificity |
Specific for the ~25k cardiac troponin I protein phosphorylated at Ser43. Immunolabeling is greatly decreased with lambda-phosphatase treatment.
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| Predicted Species |
Human (100%), Sheep (100%), Xenopus (100%), Canine (100%), Primate (100%), Bovine (100%), Zebrafish (100%). Backed by our 100% Guarantee.
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| Clonality |
Polyclonal
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| Host |
Rabbit
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| Gene |
TNNI3
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| Purity |
Immunogen affinity purified
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Applications/Dilutions
| Dilutions |
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Packaging, Storage & Formulations
| Storage |
Store at -20C. Avoid freeze-thaw cycles.
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| Buffer |
10mM HEPES (pH 7.5), 0.15M NaCl, 0.1 mg/ml BSA and 50% Glycerol
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| Preservative |
No Preservative
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| Purity |
Immunogen affinity purified
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Alternate Names for Troponin I Type 3 (cardiac) [p Ser43] Antibody
- Cardiac troponin I
- CMD1FF
- CMD2A
- CMH7MGC116817
- cTnI
- familial hypertrophic cardiomyopathy 7
- RCM1
- TNNC1troponin I, cardiac
- troponin I type 3 (cardiac)
- troponin I, cardiac muscle
Background
Troponin I (TnI) is 1 of 3 subunits, along with troponin C (TnC) and Troponin T (TnT) of troponin complex found in cardiac (cTnI) and fast skeletal (fsTnI) muscle (Noland et al, 1995). Protein kinase C-mediated phosphorylation of cardiac myofilament proteins has been shown to depress the actomyosin interaction and may be important during heart failure. (Montgomery et al, 2002) Studies indicate that phosphorylation of Ser43 and Ser45 of cardiac troponin I plays a substantial role in the PKC-mediated depression. (Montgomery et al, 2002).