Product: ONO-4061 (hydrochloride)
Troponin T Type 2 (cardiac) Antibody (1A11) Summary
| Immunogen |
Full length protein (Human).
|
| Epitope |
146-160 aa
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| Specificity |
Does not cross-react with skeletal muscle troponin T, cTnI and TnC.
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| Isotype |
IgG2b
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| Clonality |
Monoclonal
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| Host |
Mouse
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| Gene |
TNNT2
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| Purity |
Protein A purified
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Applications/Dilutions
| Dilutions |
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| Positive Control |
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| Publications |
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Reactivity Notes
Cross-reacts with Mouse, Cow, Cat, Dog, Fish, Goat, Pig, Rabbit and Human.Not yet tested in other species.
Packaging, Storage & Formulations
| Storage |
Store at 4C. Do not freeze.
|
| Buffer |
PBS (pH 7.4)
|
| Preservative |
0.09% Sodium Azide
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| Purity |
Protein A purified
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Alternate Names for Troponin T Type 2 (cardiac) Antibody (1A11)
- cardiac
- CMD1D
- CMPD2
- dilated 1D (autosomal dominant)
- hypertrophic 2
- MGC3889
- RCM3
- TnTc
- troponin T type 2 (cardiac)
- troponin T, cardiac muscle
Background
Cardiac Troponin T, a 36kDa protein, is the tropomyosin binding subunit of the troponin complex, which is located on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentration. Mutations within the protein have been associated with familial hypertrophic cardiomyopathy as well as with dilated cardiomyopathy. Transcripts for the gene undergo alternative splicing that results in many tissue specific isoforms.