alpha-Fetoprotein/AFP Antibody (MBS-12) [Alexa Fluor® 647]

Product: Trichlormethine (hydrochloride)

alpha-Fetoprotein/AFP Antibody (MBS-12) [Alexa Fluor® 647] Summary

Immunogen	Recombinant full-length human Alpha fetoprotein
Localization	Cytoplasmic
Marker	Hepatocellular/Germ Cell Tumor Marker
Specificity	It recognizes an oncofetal glycoprotein with a single chain of 70kDa, which is identified as alpha fetoprotein (AFP). This MAb is highly specific to AFP and shows no cross-reaction with other oncofetal antigens or serum albumin. The yolk sac and the liver produce AFP during fetal life. AFP expression in adults is often associated with hepatoma or teratoma. However, hereditary persistence of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the AFP and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. AFP is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of AFP in amniotic fluid is used to measure renal loss of protein to screen for spinal bifida and anencephaly.
Isotype	IgG1 Kappa
Clonality	Monoclonal
Host	Mouse
Gene	AFP
Purity	Protein A or G purified
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Applications/Dilutions

Dilutions	Flow Cytometry Immunohistochemistry-Paraffin
Application Notes	Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage	Store at 4C in the dark.
Buffer	50mM Sodium Borate
Preservative	0.05% Sodium Azide
Purity	Protein A or G purified

Notes

Alexa Flour (R) products are provided under an intellectual property license from Life Technologies Corporation. The purchase of this product conveys to the buyer the non-transferable right to use the purchased product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components, or any materials made using the product or its components, in any activity to generate revenue, which may include, but is not limited to use of the product or its components: (i) in manufacturing; (ii) to provide a service, information, or data in return for payment; (iii) for therapeutic, diagnostic or prophylactic purposes; or (iv) for resale, regardless of whether they are resold for use in research.

This product is provided under an intellectual property license from Life Technologies Corporation. The purchase of this product conveys to the buyer the non-transferable right to use the purchased product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components, or any materials made using the product or its components, in any activity to generate revenue, which may include, but is not limited to use of the product or its components: (i) in manufacturing; (ii) to provide a service, information, or data in return for payment; (iii) for therapeutic, diagnostic or prophylactic purposes; or (iv) for resale, regardless of whether they are resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5791 Van Allen Way, Carlsbad, CA 92008 USA or [email protected].

Alternate Names for alpha-Fetoprotein/AFP Antibody (MBS-12) [Alexa Fluor® 647]

AFP
Alpha-1-fetoprotein
alpha-fetoglobulin
alpha-Fetoprotein
DSCAM2
FETA
HP
HPAFP

PMID: 26588700

alpha-Fetoprotein/AFP Antibody (MBS-12) [Alexa Fluor® 647]