c-Fos Antibody (2G9C3) Summary
| Immunogen |
Synthetic peptide: KVEQLSPEEEEKRRIRRERNKMAAA, corresponding to Internal sequence amino acids 128 – 152 of Human c-Fos.
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| Localization |
Nuclear
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| Specificity |
Reacts with both cellular and viral forms, will detect both the 55 kDa and 62 kDa c-fos and v-fos proteins, but does not react with the 39 kDa jun protein.
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| Isotype |
IgG2a
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| Clonality |
Monoclonal
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| Host |
Mouse
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| Gene |
FOS
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| Purity |
Protein A or G purified
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Applications/Dilutions
| Dilutions |
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| Application Notes |
Not recommended for IHC-Paraffin sections.
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| Positive Control |
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Reactivity Notes
Please note that this antibody is reactive to Mouse and derived from the same host, Mouse. Additional Mouse on Mouse blocking steps may be required for IHC and ICC experiments. Please contact Technical Support for more information.
Packaging, Storage & Formulations
| Storage |
Store at 4C. Do not freeze.
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| Buffer |
50mM Sodium Phosphate (pH 7.5) and 0.2% Gelatin
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| Preservative |
0.1% Sodium Azide
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| Concentration |
0.2 mg/ml
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| Purity |
Protein A or G purified
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Alternate Names for c-Fos Antibody (2G9C3)
- activator protein 1
- AP-1
- cellular oncogene c-fos
- Cellular oncogene fos
- cFos
- c-Fos
- FBJ murine osteosarcoma viral (v-fos) oncogene homolog (oncogene FOS)
- FBJ murine osteosarcoma viral oncogene homolog
- FOS
- G0/G1 switch regulatory protein 7
- G0S7
- proto-oncogene c-Fos
- v-fos FBJ murine osteosarcoma viral oncogene homolog
Background
The Fos gene family consists of 4 members: Fos, FosB, FosL1, and FosL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP1. As such, the Fos proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. In some cases, expression of the Fos gene has also been associated with apoptotic cell death. The human oncogene c-Fos is homologous to the Finkel-Biskis-Jinkins (FBJ) murine osteosarcoma virus oncogene. Fos was the first transcription factor identified that has a critical function in regulating the development of cells destined to form and maintain the skeleton. Fos protein is routinely used as a marker of neuronal activation.