Ra Y, et al. (2003) Genetic variation and activity of mouse Nod2, a susceptibility gene for Crohn’s illness. Genomics 81(4):36977. 13. Bonen DK, et al. (2003) Crohn’s disease-associated NOD2 variants share a signaling defect in response to lipopolysaccharide and peptidoglycan. Gastroenterology 124(1):14046. 14. Barrett JC, et al. (2008) Genome-wide association defines greater than 30 distinct susceptibility loci for Crohn’s illness. Nat Genet 40(8):95562. 15. Strober W, Kitani A, Fuss I, Asano N, Watanabe T (2008) The molecular basis of NOD2 susceptibility mutations in Crohn’s disease. Mucosal Immunol 1(Suppl 1):S5 9. 16. Pizarro TT, et al. (2011) SAMP1/YitFc mouse strain: A spontaneous model of Crohn’s disease-like ileitis. Inflamm Bowel Dis 17(12):2566584. 17. Hisamatsu T, et al. (2003) CARD15/NOD2 functions as an antibacterial issue in human intestinal epithelial cells. Gastroenterology 124(4):993000. 18. Kim YG, et al. (2008) The cytosolic sensors Nod1 and Nod2 are vital for bacterial recognition and host defense immediately after exposure to Toll-like receptor ligands. Immunity 28(two):24657.19. Watanabe T, et al. (2008) Muramyl PLK1 Species dipeptide activation of nucleotide-binding oligomerization domain 2 protects mice from experimental colitis. J Clin Invest 118(two): 54559. 20. Olson TS, et al. (2006) The primary defect in experimental ileitis originates from a nonhematopoietic source. J Exp Med 203(three):54152. 21. Kobayashi K, et al. (2002) RICK/Rip2/CARDIAK mediates signalling for receptors with the innate and adaptive immune systems. Nature 416(6877):19499. 22. Netea MG, et al. (2005) Nucleotide-binding oligomerization domain-2 modulates precise TLR pathways for the induction of cytokine release. J Immunol 174(ten): 6518523. 23. Uehara A, et al. (2005) Muramyldipeptide and diaminopimelic acid-containing desmuramylpeptides in mixture with chemically synthesized Toll-like receptor agonists synergistically induced production of interleukin-8 inside a NOD2- and NOD1dependent manner, respectively, in human monocytic cells in culture. Cell Microbiol 7(1):531. 24. Strober W, Watanabe T (2011) NOD2, an intracellular innate immune sensor involved in host defense and Crohn’s illness. Mucosal Immunol 4(five):48495. 25. Hedl M, Li J, Cho JH, Abraham C (2007) Chronic stimulation of Nod2 mediates tolerance to bacterial goods. Proc Natl Acad Sci USA 104(49):194409445. 26. Casanova JL, Abel L (2009) Revisiting Crohn’s illness as a main immunodeficiency of macrophages. J Exp Med 206(9):1839843. 27. Marks DJ, et al. (2006) Defective acute inflammation in Crohn’s illness: A clinical investigation. Lancet 367(9511):66878. 28. Smith AM, et al. (2009) Disordered macrophage cytokine secretion underlies impaired acute inflammation and bacterial clearance in Crohn’s disease. J Exp Med 206(9): 1883897. 29. Hutti JE, et al. (2007) IkappaB kinase beta phosphorylates the K63 deubiquitinase A20 to bring about feedback inhibition on the NF-kappaB pathway. Mol Cell Biol 27(21): 7451461. 30. Bamias G, et al. (2005) Proinflammatory effects of TH2 cytokines within a murine model of chronic compact intestinal inflammation. Gastroenterology 128(three):65466. 31. Boughton-Smith NK, Wallace JL, Whittle BJ (1988) Relationship in between arachidonic acid metabolism, CDK9 review myeloperoxidase activity and leukocyte infiltration inside a rat model of inflammatory bowel illness. Agents Actions 25(1):11523. 32. Bradley PP, Priebat DA, Christensen RD, Rothstein G (1982) Measurement of cutaneous inflammation: Estimation of neutrop.