(OR 0.9 95 CI 0.90.9, P 0.05). PIP was less popular in these aged 85 years
(OR 0.9 95 CI 0.90.9, P 0.05). PIP was much less popular in these aged 85 years and above in comparison with these aged 704 yearsBradley et al. BMC Geriatrics 2014, 14:72 biomedcentral.com/1471-2318/14/Page four ofTable 1 Descriptive traits with the study population in CPRDPIP No PIP (n = 723,838) (n = 295,653) Gender -Male ( ) -Female ( ) -Missing ( ) Age (years) -704 ( ) -750 ( ) -815 ( ) – 85 ( ) Morbidities (Charlson morbidity index score) -1 ( ) -2 ( ) -3 ( ) Polypharmacy (4 medications) -Never ( ) -Ever ( ) Chronic Obructive Pulmonary Illness -No ( ) -Yes ( ) Peptic ulcer -No ( ) -Yes ( ) Diabetes -No ( ) -Yes ( ) Dementia -No ( ) -Yes ( ) Hypertension -No ( ) -Yes ( ) Osteoarthritis -No ( ) -Yes ( ) Heart failure -No ( ) -Yes ( ) Parkinsonism -No ( ) -Yes ( ) 290,071 (29.0) 709,721 (71.0) five,582 (28.3) 14,117 (71.7) 292,294 (29.0) 715,868 (71.0) three,359 (29.7) 7,970 (70.4) 216,981 (26.five) 601,325 (73.5) 78,672 (39.1) 122,513 (60.9) 140,467 (21.1) 525,316 (78.9) 155,186 (43.9) 198,522 (56.1) 283,983 (28.five) 710,985 (71.5) 11,670 (47.six) 12,853 (52.four) 225,280 (27.three) 625,591 (72.7) 70,373 (41.7) 98,247 (58.three) 274,487 (28.9) 675,938 (71.1) 21,166 (30.7) 47,900 (69.four) 277,497 (28.2) 707,447 (71.eight) 18,156 (52.six) 16,391 (47.5) 114,816 (14.6) 669,572 (85.3) 180,837 (76.9) 54,266 (23.1) 189,864 (28.three) 481,983 (71.7) 52,365 (46.eight) 53,424 (22.7) 59,519 (53.two) 182,336 (77.3) 82,177 (37.4) 92,488 (37.six) 62,407 (33.1) 58,581 (18) 137,366 (62.six) 153,778 (62.4) 126,040 (66.9) 306,654 (84) 122,817 (28.7) 304,622 (71.3) 172,834 (29.two) 419,211 (70.eight)(OR 0.5, 95 CI, 0.4-0.5, P 0.05). PIP was much more popular in these with fewer co-morbid CA I Formulation situations in line with the CCI (Table three).Prevalence of PIP employing 28 STOPP criteriaThe prevalence of PIP within the UK was 14.9 (95 CIs 14.8-14.9 ) (n = 151,598) when the subset of 28 STOPP indicators was applied. Just beneath 11 (109,808 patients) had been in receipt of at the least one particular case of PIP, while three.1 (31,693 individuals) were exposed to two or much more instances and 1.0 (ten,095 individuals) were exposed to 3 or additional. By far the most common PIP difficulties have been use of PPIs at maximum therapeutic dose for eight weeks (three.7 , 38,153 patients), NSAIDs for 3 months (3.2 32,373 individuals), and use of long-term neuroleptics (2.1 , 21,012 individuals.Discussion Following the application of 52 STOPP indicators to CPRD, the all round PIP prevalence, in those aged 70 years, inside the UK, was estimated at 29 . One of the most widespread cases of PIP have been therapeutic duplication, use of aspirin with no valid indication and inappropriate use of PPIs. PIP was related with polypharmacy and was less typical among those 85 years and above in comparison with younger age groups. It was also slightly extra popular in men. When a subset of 28 STOPP criteria, typically CCR3 Molecular Weight utilised in other research, had been applied, the overall PIP prevalence for the UK was 14.9 . Essentially the most common instances of PIP on application on the subset have been PPI use at maximum dose for higher than 8 weeks and the use of NSAIDs for 3 months. Application of the 52 STOPP indicators in CPRD enabled a more extensive estimation of PIP and highlighted added PIP challenges that had been not observed together with the truncated version with the criteria.PIP inside the UK (application of 52 indicators)Therapeutic duplication and inappropriate use of aspirin with no valid indication were the most prevalent situations of PIP within the UK and have also been reported as prevalent amongst older hospitalised individuals in Ireland [13]. Therapeutic duplication is difficult to c.
