Risk of UC. Folate, a water-soluble B vitamin in green leafy vegetables, citrus fruits, and legumes, is definitely the initial methyl donor in methionine biosynthesis [10]. Folate NPY Y1 receptor Agonist drug insufficiency disrupts the transfer of the one-carbon units involved in all biochemical reactions including plasma homocysteine determinants and SAM synthesis [11,20]. A prior study investigated the 10-y trends in plasma folate levels in Taiwanese people by way of three national NAHSIT surveys conducted in 199321996, 199922000, and 200522008 and reported similar plasma folate levels of about 8 ng/mL in men and 11 ng/mL in females; even so, the prevalence of folate deficiency (,3 ng/mL) increased in the course of these 10-y periods, particularly for men [12]. In our study, the median value of plasma folate levels was equivalent to that reported by Chen et al. but was higher than that reported in other studies [12,21,22].Association of DNMT Polymorphism and Folate together with the Threat of UCTable 2. Associations amongst the levels of plasma folate and UC threat by using multivariate logistic regression models.ORa (95 CI) 1.01 (0.99.03) ref. two.57 (1.73.84) ref. 0.42 (0.27.65) 0.44 (0.28.68) ref. 0.41 (0.26.68) 0.42 (0.26.68) 0.46 (0.28.75) ORb (95 CI) 1.02 (0.99.04) ref. 2.06 (1.34.15) ref. 0.48 (0.30.76) 0.61 (0.38.97) ref.# 0.46 (0.27.77) 0.49 (0.29.83) 0.66 (0.39.11)Plasma folate (ng/mL) Median six S.D. .6 #6 ,7.88 7.883.17 13.17 ,6.75 6.75.83 9.834.9 14.9 Incidence cases Median 6 S.D. .6 #6 ,7.88 7.883.17 13.17 ,6.75 six.75.83 9.834.9 14.9 Prevalence instances Median six S.D. .six #6 ,7.88 7.883.17 13.17 ,six.75 six.75.83 9.834.9 14.aUC patients N = 192 7.7361.23 123 (64.06) 69 (35.94) 101 (52.60) 44 (22.92) 47 (24.48) 83 (43.23) 33 (17.19) 37 (19.27) 39 (20.31) N = 104 7.2861.33c 123 (64.06) 69 (35.94) 101 (52.60) 44 (22.92) 47 (24.48) 83 (43.23) 33 (17.19) 37 (19.27) 39 (20.31) N = 88 8.4562.17c 123 (64.06) 69 (35.94) 101 (52.60) 44 (22.92) 47 (24.48) 83 (43.23) 33 (17.19) 37 (19.27) 39 (20.31)PARP1 Inhibitor Compound Controls N = 381 9.8260.37 311 (81.63) 70 (18.37) 127 (33.33) 128 (33.60) 126 (33.07) 97 (25.46) 94 (24.67) 98 (25.72) 92 (24.15) N = 381 9.8260.37 311 (81.63) 70 (18.37) 127 (33.33) 128 (33.60) 126 (33.07) 97 (25.46) 94 (24.67) 98 (25.72) 92 (24.15) N = 381 9.8260.37 311 (81.63) 70 (18.37) 127 (33.33) 128 (33.60) 126 (33.07) 97 (25.46) 94 (24.67) 98 (25.72) 92 (24.15)0.99 (0.97.02) ref. three.09 (1.90.01) ref. 0.34 (0.19.61) 0.37 (0.22.65) ref. 0.38 (0.21.71) 0.33 (0.18.62) 0.37 (0.20.68)1.01 (0.99.04) ref. two.43 (1.45.06) ref. 0.40 (0.22.73) 0.53 (0.30.95) ref. 0.44 (0.23.84) 0.39 (0.20.76) 0.53 (0.28.03)1.03 (0.99.05) ref. two.11 (1.24.60) ref. 0.52 (0.29.92) 0.50 (0.27.90) ref.# 0.44 (0.22.00) 0.53 (0.28.00) 0.56 (0.29.08)1.03 (0.99.05) ref. 1.76 (1.01.08) ref. 0.56 (0.31.01) 0.67 (0.36.25) ref. 0.45 (0.23.91) 0.60 (0.31.18) 0.76 (0.38.51)OR values had been adjusted for age and gender. OR values have been adjusted for age, gender, educational level, and cumulative cigarette smoking. p = 0.1772 by Student t-test. p,0.05 by trend test; #0.1,p,0.05 by trend test. doi:ten.1371/journal.pone.0104968.tb cMoreover, in our study, the prevalence of folate insufficiency was larger than that in other studies, ranging from five to 15 [22]. The variations in the prevalence of folate insufficiency may perhaps be attributed towards the ethnic variance of dietary habits or individual susceptibility to polymorphisms in metabolizing folate-related genes including DNMT3A and 3B. Prior research have indicated a negative association between plasma.
