D B cells exhibit considerably longer telomeres and increased telomerase activity (12). The present study aimed to investigate the cytotoxic mechanisms of CAUE in NALM-6 cells and, as shown in Fig. 1, CAUE exhibited preferential damage to DNA synthesis compared with RNA and protein synthesis. This indicated that CAUE straight affects the nucleus and impairs DNA synthesis, resulting within the induction of apoptosis. Caffeic acid phenethyl ester is actually a parent compound of CAUE and one of its pharmacological mechanisms of DNA harm includes the inhibition of nuclear issue B (NF- B) (13). Caffeic acid derivatives block NF- B PLK1 Inhibitor Compound activation (7), and it has been hypothesized that NF- B inhibitory molecules are clinically effective as single therapeutic agents or in combination with classical chemotherapeutic agents for the remedy of hematological malignancies (14). For that reason, CAUE may well inhibit NF- B in leukemia cells and damage DNA to trigger the induction of apoptosis. NF- B regulates hTERT expression by binding to a internet site 350-bp upstream on the translational initiation web page (15). Also, it has been reported that telomerase straight regulates NF- B-dependent genes in cancer cells (16). As a result, there is a close correlation amongst NF- B and telomerase activity. The results of the present study indicate that CAUE inhibits telomerase activation by means of mediation of hTERT protein expression, hence, we hypothesize that the inhibition by CAUE is dependent on the inhibition of NF- B activation.In conclusion, CAUE inhibits DNA synthesis and suppresses telomerase activity. Targeting the inhibition of telomerase has been hypothesized to become effective for cancer chemotherapy due to its selectivity against malignant cells, thereby decreasing side-effects. Telomerase inhibition is probably to be tested on humans inside the future, in an effort to treat lymphoid cancers, including B-cell leukemia (17). The observations in the present study could hence help the improvement of therapeutic approaches for leukemia sufferers.
Open Access Case ReportLaparoscopic removal of an intrauterine device from the mGluR5 Antagonist MedChemExpress sigmoid colonFatih anlikan1, Ouz Arslan2, Muhittin Eftal Avci3, Ahmet G men4 ABSTRACT Uterine wall perforation which can be usually observed through the posterior wall of the uterus would be the most seriouscomplicationofanintrauterinedevice(IUD).WepresentacaseoflaparoscopicremovalofanIUD fromthesigmoidcolonina31-years-oldfemalewhowasadmittedtohospitalwithahistoryofpelvicpain andabnormalvaginalbleedingforonemonth.ThedislocatedIUDwasremovedfromthesigmoidcolonof laparoscopicinterventionwithoutanycomplications. In conclusion, the treatment modality for the removal of a dislocated IUD is achievable by laparoscopic surgeryinselectedpatientswherethedislocatedIUDisaccessible. Important WORDS: Dislocatedintrauterinedevice,Laparoscopicsurgery.doi: dx.doi.org/10.12669/pjms.311.How you can cite this:anlikan F, Arslan O, Avci ME, G males A. Laparoscopic removal of an intrauterine device in the sigmoid colon. Pak J Med Sci 2015;31(1):214-216. doi: dx.doi.org/10.12669/pjms.311.ThisisanOpenAccessarticledistributedunderthetermsoftheCreativeCommonsAttributionLicense(creativecommons.org/licenses/by/3.0), whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperlycited.INTRODUCTION The usage of an intrauterine device as a contraceptive method is extremely typical within the planet, in particular in creating countries. In Turkey, where the fertility rates are slightly greater than the world.
