Participate Not applicable. Author facts 1 Experimental Surgery, Division of Common, Visceral, Vascular, and Pediatric Surgery, University Hospital of W zburg, Oberd rbacher Str. 6, D-97080 W zburg, Germany. 2Present Address: Spital B ach, Medizinische Klinik, Spitalstrasse 24, 8180 B ach, Germany. 3Present Address: Missions ztliche Klinik, Fachabteilung Urologie, Salvatorstra 7, 97074 W zburg, Germany. 4Present Address: Klinik f Allgemein-, Viszeral-, Gef und Thoraxchirurgie, Krankenhaus Leopoldina der Stadt Schweinfurt, Gustav-Adolf-Stra 8, 97422 Schweinfurt, Germany. 5Department of Common, Visceral, Vascular and Pediatric Surgery, University Hospital of W zburg, Oberd rbacher Str. 6, D-97080 W zburg, Germany. 6Department of Biochemistry and Molecular Biology, Theodor-Boveri-Institute, Biocenter, University of W zburg, D-97070 W zburg, Germany. 7Department of Obstetrics and Gynaecology, University Hospital of W zburg, Josef-Schneider-Str. 4, D-97080 W zburg, Germany. Received: three September 2015 Accepted: 25 MayAbbreviations ATP, adenosine triphosphate; CV, crystal violet; DCFH-DA, two,7-dichlorofluorescin diacetate; DMBQ, two,6-dimethoxy-1,4-benzoquinone; FWGE, fermented wheat germ extract; IC50, half maximal inhibitory concentration; NAD, nicotinamide adenine dinucleotide; PBS, phosphate buffered saline; RFU, relative fluorescence units; ROS, reactive oxygen species.Acknowledgements The authors are grateful to Sabine Gahn, Manuela Hofmann, Michaela Kapp, Monika Koospal, and Bettina M ling for their skillful assistance using the experiments.BMP-2 Protein MedChemExpress References 1.IFN-beta Protein medchemexpress Heimbach JT, Sebestyen G, Semjen G, Kennepohl E.PMID:25269910 Safety research regarding a standardized extract of fermented wheat germ. Int J Toxicol. 2007;26(3):253. 2. Hidv i M, R E, T k i-Farkas R, Paku S, Lapis K, Szende B. Impact of Avemar and Avemar + Vitamin C on tumor development and metastasis in experimental animals. Anticancer Res. 1998;18:2353. 3. Hidv i M, R E, T k i-Farkas R, Szende B, Paku S, Pr ai L, et al. MSC, a brand new benzoquinone-containing all-natural product with antimetastatic effect. Cancer Biother Radiopharm. 1999;14(4):2779. four. Jakab F, Shoenfeld Y, Balogh Nichelatti A, Kah Z, Lapis K, et al. A medical nutriment has supportive worth inside the remedy of colorectal cancer. Br J Cancer. 2003;89:465. 5. Demidov LV, Manziuk LV, Kharkevitch GY, Pirogova NA, Artamonova EV. Adjuvant fermented wheat germ extract (Avemar) nutraceutical improves survival of high threat skin melanoma patients: a randomized pilot phase II clinical study with a 7-year follow-up. Cancer Biother Radiopharm. 2008;23(four):4772. 6. O’Brien PJ. Molecular mechanisms of quinone cytotoxicity. Chem Biol Interact. 1991;80:11. 7. Piccart-Gebhart MJ. Anthracyclines along with the tailoring of remedy for early breast cancer. N Engl J Med. 2006;354(20):2177. 8. Bachur NR, Gordon SL, Gee MV. A basic mechanism of microsomal activation of quinone anticancer agents to no cost radical. Cancer Res. 1978;38:17450.Otto et al. BMC Complementary and Option Medicine (2016) 16:Page ten of9.10. 11. 12. 13.14.15. 16.17.18.19.20.21. 22.23.24. 25. 26.27. 28. 29. 30.31.32.Pethig R, Gascoyne PRC, McLaughlin JA, Szent-Gy gyi A. Ascorbatequinone interactions: electrochemical, absolutely free radical and cytotoxic properties. Proc Natl Acad Sci U S A. 1983;80:1292. Winterbourn CC. Reconciling the chemistry and biology of reactive oxygen species. Nat Chem Biol. 2008;4(5):2786. Circu ML, Aw TY. Glutathione and modulation of cell apoptosis. Biochim Biophys Acta.
