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Ect Dis. 2010; 51:35058. [PubMed: 20583924] * 1st description of KSHV-associated inflammatory cytokine syndrome (KICS). five. Cotter MA 2nd, Robertson ES. The latency-associated nuclear antigen tethers the Kaposi’s sarcomaassociated herpesvirus genome to host chromosomes in physique cavity-based lymphoma cells. Virology. 1999; 264:25464. [PubMed: 10562490] six. Guasparri I, Keller SA, Cesarman E. KSHV vFLIP is crucial for the survival of infected lymphoma cells. J Exp Med. 2004; 199:993003. [PubMed: 15067035] 7. Lee HR, Amatya R, Jung JU. Multi-step regulation of innate immune signaling by Kaposi’s sarcoma-associated herpesvirus. Virus Res. 2015; 209:394. [PubMed: 25796211] * Description of how KSHV modulated the innate immune response. 8. Valiya Veettil M, Dutta D, Bottero V, et al. Glutamate secretion and metabotropic glutamate receptor 1 expression through Kaposi’s sarcoma-associated herpesvirus infection promotes cell proliferation. PLoS Pathog. 2014; ten:e1004389. [PubMed: 25299066] ** This is the first significant study in the roles from the glutamate receptor with KSHV infection.Ursocholic acid Autophagy Repression of glutamate release and receptor function final results in suppression of proliferation of KSHV-infected cells. 9. Davis DA, Rinderknecht AS, Zoeteweij JP, et al. Hypoxia induces lytic replication of Kaposi sarcoma-associated herpesvirus. Blood. 2001; 97:3244250. [PubMed: 11342455] 10.Leukotriene B4 Data Sheet Hu D, Wang V, Yang M, et al. Induction of Kaposi’s Sarcoma-Associated Herpesvirus-Encoded Viral Interleukin-6 by X-Box Binding Protein 1. J Virol. 2016; 90:36878. [PubMed: 26491160] * This study reports expression of viral interleukin-6 (vIL6) in lymph nodes of patients with KSHV-associated multicentric Castleman’s illness. Expression of vIL6 is often induced by X-box binding protein. 11. Rivas C, Thlick AE, Parravicini C, et al. Kaposi’s sarcoma-associated herpesvirus LANA2 is really a Bcell-specific latent viral protein that inhibits p53. J Virol. 2001; 75:42938. [PubMed: 11119611] 12. Chang HH, Ganem D. A distinctive herpesviral transcriptional plan in KSHV-infected lymphatic endothelial cells results in mTORC1 activation and rapamycin sensitivity. Cell Host Microbe. 2013; 13:42940. [PubMed: 23601105] 13. Dukers NH, Renwick N, Prins M, et al. Danger variables for human herpesvirus 8 seropositivity and seroconversion inside a cohort of homosexual men. Am J Epidemiol. 2000; 151:21324. [PubMed: 10670545] 14. Pauk J, Huang ML, Brodie SJ, et al. Mucosal shedding of human herpesvirus eight in guys. N Engl J Med.PMID:27217159 2000; 343:1369377. [PubMed: 11070101] 15. Martin JN, Ganem DE, Osmond DH, et al. Sexual transmission as well as the all-natural history of human herpesvirus eight infection. N Engl J Med. 1998; 338:94854. [PubMed: 9521982]Curr Opin HIV AIDS. Author manuscript; readily available in PMC 2018 December 31.Goncalves et al.Page16. Koelle DM, Huang ML, Chandran B, et al. Frequent detection of Kaposi’s sarcoma-associated herpesvirus (human herpesvirus 8) DNA in saliva of human immunodeficiency virus-infected males: clinical and immunologic correlates. J Infect Dis. 1997; 176:9402. [PubMed: 9207354] 17. Butler LM, Osmond DH, Jones AG, et al. Use of saliva as a lubricant in anal sexual practices among homosexual guys. J Acquir Immune Defic Syndr. 2009; 50:16267. [PubMed: 19131893] 18. Rohner E, Wyss N, Heg Z, et al. HIV and human herpesvirus eight co-infection across the globe: Systematic overview and meta-analysis. Int J Cancer. 2016; 138:454. [PubMed: 26175054] ** This systematic overview describes research reporting the prevalence of KSHV in H.

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