Product Name :
NLRP3-IN-NBC6
Description:
NLRP3-IN-NBC6 is a potent, selective NLRP3 inflammasome inhibitor (IC50= 574 nM) that acts independently of Ca2+. NLRP3-IN-NBC6 inhibits Nigericin (HY-127019)-induced inflammasome activation in THP-1 cells and Imiquimod (HY-B0180)-induced IL-1β release from LPS-primed bone marrow-derived macrophages (BMDMs).
CAS:
2068818-02-8
Molecular Weight:
409.50
Formula:
C18H16BCl3N2O2
Chemical Name:
5-acetyl-6-amino-2,2-diphenyl-4-(trichloromethyl)-2H-1,3,2-oxazaborinin-3-ium-2-uide
Smiles :
CC(=O)C1=C(N)O[B-]([NH+]=C1C(Cl)(Cl)Cl)(C1C=CC=CC=1)C1C=CC=CC=1
InChiKey:
VKECODDKRKQJNM-UHFFFAOYSA-N
InChi :
InChI=1S/C18H16BCl3N2O2/c1-12(25)15-16(18(20,21)22)24-19(26-17(15)23,13-8-4-2-5-9-13)14-10-6-3-7-11-14/h2-11,24H,23H2,1H3
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{SQ109} medchemexpress|{SQ109} Parasite|{SQ109} Biological Activity|{SQ109} References|{SQ109} manufacturer|{SQ109} Cancer}
Shelf Life:
≥12 months if stored properly.{{Siltuximab} medchemexpress|{Siltuximab} Immunology/Inflammation|{Siltuximab} Biological Activity|{Siltuximab} Purity|{Siltuximab} custom synthesis|{Siltuximab} Autophagy}
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
NLRP3-IN-NBC6 is a potent, selective NLRP3 inflammasome inhibitor (IC50= 574 nM) that acts independently of Ca2+. NLRP3-IN-NBC6 inhibits Nigericin (HY-127019)-induced inflammasome activation in THP-1 cells and Imiquimod (HY-B0180)-induced IL-1β release from LPS-primed bone marrow-derived macrophages (BMDMs).PMID:26446225 |Product information|CAS Number: 2068818-02-8|Molecular Weight: 409.50|Formula: C18H16BCl3N2O2|Chemical Name: 5-acetyl-6-amino-2,2-diphenyl-4-(trichloromethyl)-2H-1,3,2-oxazaborinin-3-ium-2-uide|Smiles: CC(=O)C1=C(N)O[B-]([NH+]=C1C(Cl)(Cl)Cl)(C1C=CC=CC=1)C1C=CC=CC=1|InChiKey: VKECODDKRKQJNM-UHFFFAOYSA-N|InChi: InChI=1S/C18H16BCl3N2O2/c1-12(25)15-16(18(20,21)22)24-19(26-17(15)23,13-8-4-2-5-9-13)14-10-6-3-7-11-14/h2-11,24H,23H2,1H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|In LPS-primed primary BMDMs, NLRP3-IN-NBC6 (10 μM; 15 minutes) inhibits Imiquimod-induced IL-1β release. NLRP3-IN-NBC6 completely inhibits NLRP3-dependent IL-1β release in neutrophils (neutrophils were isolated from WT and NLRP3 KO murine bone marrow and primed with LPS followed by Nigericin treatment in the presence of 10 μM NLRP3-IN-NBC6).|Products are for research use only. Not for human use.|
