Product Name :
S0859
Description:
S0859 is a selective, high-affinity generic NBC inhibitor, potentially important for probing the transporter’s functional role in heart and other tissues. S0859 reversibly inhibited NBC-mediated pH(i) recovery (K (i)=1.7 microM, full inhibition at approximately 30 microM). In HEPES-buffered superfusates, NHE-mediated pH(i) recovery was unaffected by 30 microM S0859. With CO(2)/HCO(3) (-) buffer, pH(i) recovery from intracellular alkalosis (mediated by Cl(-)/HCO(3) (-) and Cl(-)/OH(-) exchange) was also unaffected. .
CAS:
1019331-10-2
Molecular Weight:
530.04
Formula:
C29H24ClN3O3S
Chemical Name:
2-chloro-N-{[2′-(cyanosulfamoyl)-[1,1′-biphenyl]-4-yl]methyl}-N-[(4-methylphenyl)methyl]benzamide
Smiles :
CC1C=CC(CN(CC2C=CC(=CC=2)C2=CC=CC=C2S(=O)(=O)NC#N)C(=O)C2=CC=CC=C2Cl)=CC=1
InChiKey:
ITDBPOSLOROLMT-UHFFFAOYSA-N
InChi :
InChI=1S/C29H24ClN3O3S/c1-21-10-12-22(13-11-21)18-33(29(34)26-7-2-4-8-27(26)30)19-23-14-16-24(17-15-23)25-6-3-5-9-28(25)37(35,36)32-20-31/h2-17,32H,18-19H2,1H3
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥360 days if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
S0859 is a selective, high-affinity generic NBC inhibitor, potentially important for probing the transporter’s functional role in heart and other tissues. S0859 reversibly inhibited NBC-mediated pH(i) recovery (K (i)=1.{{Oclacitinib} web|{Oclacitinib} JAK/STAT Signaling|{Oclacitinib} Biological Activity|{Oclacitinib} In Vitro|{Oclacitinib} manufacturer|{Oclacitinib} Autophagy} 7 microM, full inhibition at approximately 30 microM).{{Cariprazine} web|{Cariprazine} 5-HT Receptor|{Cariprazine} Biological Activity|{Cariprazine} In Vivo|{Cariprazine} manufacturer|{Cariprazine} Autophagy} In HEPES-buffered superfusates, NHE-mediated pH(i) recovery was unaffected by 30 microM S0859.PMID:24187611 With CO(2)/HCO(3) (-) buffer, pH(i) recovery from intracellular alkalosis (mediated by Cl(-)/HCO(3) (-) and Cl(-)/OH(-) exchange) was also unaffected. .|Product information|CAS Number: 1019331-10-2|Molecular Weight: 530.04|Formula: C29H24ClN3O3S|Chemical Name: 2-chloro-N-{[2′-(cyanosulfamoyl)-[1,1′-biphenyl]-4-yl]methyl}-N-[(4-methylphenyl)methyl]benzamide|Smiles: CC1C=CC(CN(CC2C=CC(=CC=2)C2=CC=CC=C2S(=O)(=O)NC#N)C(=O)C2=CC=CC=C2Cl)=CC=1|InChiKey: ITDBPOSLOROLMT-UHFFFAOYSA-N|InChi: InChI=1S/C29H24ClN3O3S/c1-21-10-12-22(13-11-21)18-33(29(34)26-7-2-4-8-27(26)30)19-23-14-16-24(17-15-23)25-6-3-5-9-28(25)37(35,36)32-20-31/h2-17,32H,18-19H2,1H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥360 days if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|
