Product Name :
YM-53601 free base
Description:
YM-53601 free base is a squalene synthetase inhibitor which suppresses lipogenic biosynthesis and lipid secretion in rodents.
CAS:
182959-28-0
Molecular Weight:
336.40
Formula:
C21H21FN2O
Chemical Name:
2-{2-[(3E)-1-azabicyclo[2.2.2]octan-3-ylidene]-2-fluoroethoxy}-9H-carbazole
Smiles :
F/C(/COC1=CC2NC3C=CC=CC=3C=2C=C1)=C1/CN2CCC/1CC2
InChiKey:
XNDCPFTULXRWQH-HNENSFHCSA-N
InChi :
InChI=1S/C21H21FN2O/c22-19(18-12-24-9-7-14(18)8-10-24)13-25-15-5-6-17-16-3-1-2-4-20(16)23-21(17)11-15/h1-6,11,14,23H,7-10,12-13H2/b19-18-
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
YM-53601 free base is a squalene synthetase inhibitor which suppresses lipogenic biosynthesis and lipid secretion in rodents.|Product information|CAS Number: 182959-28-0|Molecular Weight: 336.40|Formula: C21H21FN2O|Chemical Name: 2-{2-[(3E)-1-azabicyclo[2.2.2]octan-3-ylidene]-2-fluoroethoxy}-9H-carbazole|Smiles: F/C(/COC1=CC2NC3C=CC=CC=3C=2C=C1)=C1/CN2CCC/1CC2|InChiKey: XNDCPFTULXRWQH-HNENSFHCSA-N|InChi: InChI=1S/C21H21FN2O/c22-19(18-12-24-9-7-14(18)8-10-24)13-25-15-5-6-17-16-3-1-2-4-20(16)23-21(17)11-15/h1-6,11,14,23H,7-10,12-13H2/b19-18-|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Thio-TEPA} site|{Thio-TEPA} Bacterial|{Thio-TEPA} Activator|{Thio-TEPA} Purity & Documentation|{Thio-TEPA} References|{Thio-TEPA} custom synthesis} |Shelf Life: ≥12 months if stored properly.{{Famoxadone} web|{Famoxadone} Anti-infection|{Famoxadone} Activator|{Famoxadone} Purity & Documentation|{Famoxadone} Formula|{Famoxadone} manufacturer} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:35345980 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vivo:|YM-53601 inhibits cholesterol biosynthesis from acetate in a dose-dependent manner in the plasma of rats. At the same time, YM-53601 inhibits both FFA and triglyceride biosynthesis in rats treated with cholestyramine over the same dose range at which it inhibits cholesterol biosynthesis. YM-53601 by single oral administration decreases the enhanced plasma triglyceride levels in hamsters induced by an injection of protamine sulfate, which inhibits lipoprotein lipase (LPL) and consequently increases plasma very low-density lipoprotein (VLDL) triglyceride levels. YM-53601 also decreases the enhanced plasma triglyceride and cholesterol levels in hamsters treated with Triton WR1339, which also inhibits the degradation of VLDL. Plasma cholesterol was significantly decreased as soon as 1 h after single administration of YM-53601 in hamsters fed a normal diet.|Products are for research use only. Not for human use.|
