Product Name :
MDR-652
Description:
MDR-652 is a highly specific and efficacious transient receptor potential vanilloid 1 (TRPV1) ligand with agonist activity. The Kis are 11.4 and 23.8 nM for hTRPV1 and rTRPV1, respectively. The EC50s are 5.05 and 93 nM for hTRPV1 and rTRPV1, respectively. Potent topical analgesic activity.
CAS:
1933528-96-1
Molecular Weight:
447.95
Formula:
C22H23ClFN3O2S
Chemical Name:
3-{[2-tert-butyl-4-(3-chlorophenyl)-1,3-thiazol-5-yl]methyl}-1-[3-fluoro-4-(hydroxymethyl)phenyl]urea
Smiles :
CC(C)(C)C1=NC(=C(CNC(=O)NC2=CC=C(CO)C(F)=C2)S1)C1=CC=CC(Cl)=C1
InChiKey:
HKMPJRGWSUCANB-UHFFFAOYSA-N
InChi :
InChI=1S/C22H23ClFN3O2S/c1-22(2,3)20-27-19(13-5-4-6-15(23)9-13)18(30-20)11-25-21(29)26-16-8-7-14(12-28)17(24)10-16/h4-10,28H,11-12H2,1-3H3,(H2,25,26,29)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
MDR-652 is a highly specific and efficacious transient receptor potential vanilloid 1 (TRPV1) ligand with agonist activity. The Kis are 11.4 and 23.8 nM for hTRPV1 and rTRPV1, respectively. The EC50s are 5.05 and 93 nM for hTRPV1 and rTRPV1, respectively. Potent topical analgesic activity.|Product information|CAS Number: 1933528-96-1|Molecular Weight: 447.95|Formula: C22H23ClFN3O2S|Chemical Name: 3-{[2-tert-butyl-4-(3-chlorophenyl)-1,3-thiazol-5-yl]methyl}-1-[3-fluoro-4-(hydroxymethyl)phenyl]urea|Smiles: CC(C)(C)C1=NC(=C(CNC(=O)NC2=CC=C(CO)C(F)=C2)S1)C1=CC=CC(Cl)=C1|InChiKey: HKMPJRGWSUCANB-UHFFFAOYSA-N|InChi: InChI=1S/C22H23ClFN3O2S/c1-22(2,3)20-27-19(13-5-4-6-15(23)9-13)18(30-20)11-25-21(29)26-16-8-7-14(12-28)17(24)10-16/h4-10,28H,11-12H2,1-3H3,(H2,25,26,29)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 250 mg/mL (558.10 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Anti-Mouse IL-1b Antibody} site|{Anti-Mouse IL-1b Antibody} Interleukin Related|{Anti-Mouse IL-1b Antibody} Protocol|{Anti-Mouse IL-1b Antibody} In Vitro|{Anti-Mouse IL-1b Antibody} custom synthesis|{Anti-Mouse IL-1b Antibody} Autophagy} |Shelf Life: ≥12 months if stored properly.{{Ponezumab} medchemexpress|{Ponezumab} Glutaminase|{Ponezumab} Protocol|{Ponezumab} Formula|{Ponezumab} manufacturer|{Ponezumab} Autophagy} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:33232044 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vivo:|MDR-652 (0.5 and 5 mg/kg) displays a dose-dependent decrease of body temperature, supporting that MDR-652 displays TRPV1 agonism in the intact animal. MDR-652 (5-10 mg/kg; i.p. and s.c.) blocks the neuropathic pain completely, indicating 100% maximum possible effect (MPE) . MDR-652 has a promising topical pharmacokinetic profile. MDR-652 has no significant toxicity. In a single-dose toxicity study, the LD50 of MDR-652 is higher than 200 and 2000 mg/kg in i.p. and p.o. administration, respectively.|Products are for research use only. Not for human use.|
