Name :
Profilin 4 Protein
Description :
PFN4, also known as profilin 4, is a member of the profilin family. Profilin can be detected in all eukaryotic organisms. It plays an important role in the spatially and temporally controlled growth of actin microfilaments. Profilin is one of the most abundant actin monomer binders, but proteins such as CAP and (in mammals) thymosin β4 have some functional overlaps with profilin. In contrast, ADF/cofilin has some properties that antagonize profilin action. PFN4 also functions in the dynamic turnover and restructuring of the actin cytoskeleton.
Species :
Human
Uniprotkb :
E. coli
Tag :
His
Synonyms :
profilin family, member 4
Construction :
A DNA sequence encoding the human PFN4 (NP_955378.1) (Met1-Ser129) was expressed with a polyhistide tag at the N-terminus.
Protein Purity :
> 95 % as determined by SDS-PAGE
Molecular Weight :
Approxiamtely 16.2 kDa
Endotoxin :
Please contact us for more information.
Formulatione :
Lyophilized from sterile PBS, 200mM Arg, pH 7.4. Please contact us for any concerns or special requirements. Normally 5 % – 8 % trehalose, mannitol and 0. 01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
Reconstitution :
A hardcopy of datasheet with reconstitution instructions is sent along with the products. Please refer to it for detailed information.
Stability & Storage :
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Shipping :
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Research Background :
PFN4, also known as profilin 4, is a member of the profilin family. Profilin can be detected in all eukaryotic organisms. It plays an important role in the spatially and temporally controlled growth of actin microfilaments. Profilin is one of the most abundant actin monomer binders, but proteins such as CAP and (in mammals) thymosin β4 have some functional overlaps with profilin. In contrast, ADF/cofilin has some properties that antagonize profilin action. PFN4 also functions in the dynamic turnover and restructuring of the actin cytoskeleton.
References and Literature :
1. Di Nardo A. et al., 2000, J Cell Sci. 113 (21): 3795-803. 2. Witke W. et al., 1998, EMBO J. 17 (4): 967-76. 3. Carlsson L. et al., 1977, J Mol Biol. 115 (3): 465-83.
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