Name :
PRL-1/PTP4A1 Protein
Description :
Phosphatases of regenerating liver (PRL-1, PRL-2, and PRL-3, also known as PTP4A1, PTP4A2, and PTP4A3) control magnesium homeostasis through an association with the CNNM magnesium transport regulators. PRL-1 (PTP4A1) is a key molecule that activates tyrosine phosphorylation, which is important for cancer progression and metastasis.
Species :
Human
Uniprotkb :
E. coli
Tag :
N-His
Synonyms :
PTPCAAX1, PRL1, PRL-1, PTP(CAAXI), PTP4A1
Construction :
Recombinant Human PRL-1/PTP4A1 Protein is expressed from E.coli with His tag at the N-Terminus. It contains Met1-Cys170.[Accession |Q93096]
Protein Purity :
> 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC
Molecular Weight :
The protein has a predicted MW of 20.56 kDa same as Tris-Bis PAGE result.
Endotoxin :
Less than 1EU per μg by the LAL method.
Formulatione :
Supplied as 0.22μm filtered solution in 20mM Tris, 250mM NaCl, 1mM DTT, 20% Glycerol (pH 7.4).
Reconstitution :
Stability & Storage :
Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Shipping :
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Research Background :
Phosphatases of regenerating liver (PRL-1, PRL-2, and PRL-3, also known as PTP4A1, PTP4A2, and PTP4A3) control magnesium homeostasis through an association with the CNNM magnesium transport regulators. PRL-1 (PTP4A1) is a key molecule that activates tyrosine phosphorylation, which is important for cancer progression and metastasis.
References and Literature :
1. Hardy S, et al. Magnesium-sensitive upstream ORF controls PRL Phosphatase expression to mediate energy metabolism. Proc Natl Acad Sci U S A. 2019 Feb 19;116(8):2925-2934. doi: 10.1073/pnas.1815361116. Epub 2019 Feb 4. PMID: 30718434; PMCID: PMC6386685. 2. Song Q, et al. PTP4A3 Is a Prognostic Biomarker Correlated With Immune Infiltrates in Papillary Renal Cell Carcinoma. Front Immunol. 2021 Sep 23;12:717688. doi: 10.3389/fimmu.2021.717688. PMID: 34630392; PMCID: PMC8495008.
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