Shizukaol C

Description:
Shizukaol C is a drug-resistant molecule that has been shown to be active against leukemia cells, pancreatic cancer cells, and carcinoma cells. Shizukaol C inhibits the growth of cancer cells by targeting the fatty acid synthesis pathway. The hydroxy group in Shizukaol C interacts with the enzyme ATP citrate lyase, which is involved in fatty acid synthesis. This interaction prevents ATP citrate lyase from functioning properly and blocks the production of fatty acids. Shizukaol C also interacts with other enzymes such as acetyl-CoA carboxylase and ACC-acetyltransferase, which are vital for fatty acid synthesis. These interactions inhibit the production of fatty acids and thereby prevent cell division. Shizukaol C has also been shown to have antifungal properties due to its ability to inhibit fungal growth through inhibition of ergosterol biosynthesis.