Whole exome sequencing of patients with various myeloid malignancies revealed recurrent somatic mutations in SETBP1, consistent with findings in atypical chronic myeloid leukemia (aCML). Closely positioned mutations at p.Asp868, p.Ser869,…
In Tanzania, the introduction of sulphadoxine-pyrimethamine (SP) as first-line treatment for uncomplicated malaria in 2001 marked a significant shift from chloroquine, which had been used since the 1970s. However, resistance…
Smad32/2 mice exhibit heightened susceptibility to dextran sodium sulfate (DSS)-induced colitis and colon cancer compared to their wild-type counterparts. This model provides a robust platform for studying inflammation-driven tumorigenesis, particularly…
MicroRNA-21 (miR-21) is consistently upregulated in various inflammatory diseases, yet its precise role in gut inflammation and tissue damage remains poorly defined. This study aimed to elucidate the function of…
Lysosomes are acidic intracellular organelles with a pH ranging from 4.5 to 5.0, playing a critical role in cellular homeostasis through the degradation of macromolecules, autophagy, and apoptosis. Among their…
**Background** Epilepsy is a chronic neurological disorder characterized by recurrent, unprovoked seizures resulting from excessive electrical discharges in the brain. A primary therapeutic strategy for managing epilepsy involves modulating the…
The density and type of lymphocytes infiltrating colon tumors are key predictors of clinical outcomes in colorectal cancer. High levels of TH17 cells and associated inflammation correlate with poor prognosis,…
**Background** The ability to rapidly and selectively deplete a specific protein from a cellular system is a powerful tool for analyzing protein function and validating therapeutic targets. Traditional genetic approaches,…
The freshwater climbing perch, *Anabas testudineus*, is a highly adaptable teleost capable of surviving in diverse environments, including freshwater, seawater, and terrestrial conditions. This adaptability is supported by its unique…
**Background** Liver X receptors (LXRs) play a critical role in maintaining cholesterol homeostasis and regulating inflammatory responses. In the context of type 2 diabetes, dysfunction in the LXR pathway often…