oactivation is CYP1A1. Hence, inducing substances of the CYP1A group may possibly facilitate the formation of reactive metabolites and enhance the risk of toxicity related to myristicin. Even so, myristicin was also evaluated for its likely ability to inhibit CYP complex enzymes, as well as the benefits showed that myristicin exerts some inhibitory effect on human CYP2E1, CYP2C19, and CYP1A2 but exerts the strongest inhibitory impact on CYP1A2 [9,10,13].Molecules 2021, 26,ordinarily develop just after consuming 10 to 15 g of nutmeg, or about 400 mg of myristicin (corresponding to 6 mg/kg). Anticholinergic effects occur right after ingestion of 25 to 28 g of nutmeg. Symptoms could seem three to 6 h right after administration and persist for up to 72 h. The key symptoms reported are: dry mouth, facial flushing, blurred vision, hypertension, tachycardia, psychomotor agitation and restlessness; in more extreme instances, individuals 3 of 15 develop delusions, dissociative episodes and visual, auditory or tactile hallucinations [11,13,14].Figure 1. Molecular structure of myristicin and its active metabolite MMDA [9]. Figure 1. Molecular structure of myristicin and its active metabolite MMDA [9].Soon after phase two metabolism, myristicin metabolites are in a position to form complexes with Although potentially serious, cases of accidental poisoning are relatively uncommon, as it is endogenous N-acetylcysteine, forming the myristicin-NAC complex, also as glutathione, essential to myristicin-GSH complicated. These complexes are mostly eliminated in urine [9,10]. forming the ingest a large αvβ1 list amount of nutmeg to attain a plasma NPY Y1 receptor supplier concentration of myristicin capable oftoxic effectssuch effects. Only 1 fatal case of poisoning was reported for a boy, The advertising of myristicin are dose-dependent. Neuropsychological symptoms aged eight, who ate two nutmegs and passed15 g ofcomatose condition400 mg a case study, generally develop right after consuming 10 to into a nutmeg, or about [15]. In of myristicin a 29-year-old male patient who had ingested about 3 to occur soon after ingestion to 28 g) pre(corresponding to 6 mg/kg). Anticholinergic effects 4 complete walnuts (18 of 25 to 28 g sented unmotivated laughter, disorganized just after administration and persist for up to 72 h. of nutmeg. Symptoms may possibly seem 3 to six h speech and psychomotor agitation, evolving to remission within the following days. dry mouth, facial flushing, blurredintoxication of a norThe most important symptoms reported are: An additional case study describes the vision, hypertension, mally creating 3-month-old infant who presented repeated episodes of afebrile status tachycardia, psychomotor agitation and restlessness; in much more severe cases, individuals develop epilepticus dissociative episodes and visual, auditory or tactile hallucinations [11,13,14]. delusions, immediately after ingestion of nutmeg. Phenytoin, phenobarbital and midazolam had been administered to manage the seizures, casesthe accidental poisoning are reasonably uncommon, since it is Even though potentially severe, and of patient progressed to improvement, with no new epilepticingest a sizable level of nutmeg to attain a plasma concentration of myristicin necessary to episodes [11,14]. From advertising such effects. Only a single that myristicin and its active metabolites capable ofthese information, it really is attainable to observe fatal case of poisoning was reported for any have aged 8, who ate two nutmegs and passed into a comatose situation [15]. Indue to boy, psychoactive activity, that is primarily responsible for its toxicity. Nonetheless, a case this activity, it could al
