Thank our patients and their households for participating in our analysis. Received for publication October 24, 2012, and accepted in revised form April 11, 2013. Address correspondence to: Joseph H. Callicott, Head, Unit on Dynamic Imaging Genetics, Clinical Brain Issues Branch, DIRP, NIMH, NIH, ten Center Drive, Room 3C-117, MSC 1379, Bethesda, Maryland 20892-1379, USA. Telephone: 301.402.3018; Fax: 301.480.7795; E-mail: [email protected] interactions in neuroimaging. Neuroimage. 1997;6(three):21829. 19. Huffaker SJ, et al. A primate-specific, brain isoform of KCNH2 affects cortical physiology, cognition, neuronal repolarization and danger of schizophrenia. Nat Med. 2009;15(five):50918. 20. Mier D, Kirsch P, Meyer-Lindenberg A. Neural substrates of pleiotropic action of genetic variation in COMT: a meta-analysis. Mol Psychiatry. 2010;15(9):91827. 21. Meyer-Lindenberg AS, et al. Regionally precise disturbance of dorsolateral prefrontal-hippocampal functional connectivity in schizophrenia.Inosine Arch Gen Psychiatry. 2005;62(4):37986. 22. Weinberger DR, Levitt P. Neurodevelopmental origins of schizophrenia. In: Weinberger DR, Harrison PJ, eds. Schizophrenia. 3rd ed. Oxford, United kingdom: Wiley-Blackwell; 2011:39312. 23. Zuk O, Hechtera E, Sunyaev SR, Lander ES. The mystery of missing heritability: Genetic interactions make phantom heritability. Proc Natl Acad Sci U S A. 2012;109(4):1193198. 24. Klassen R, et al. Exome sequencing of ion channel genes reveals complex profiles confounding individual threat assessment in epilepsy. Cell. 2011;145(7):1036048. 25. Huang W, et al. Epistasis dominates the genetic architecture of Drosophila quantitative traits. Proc Natl Acad Sci U S A. 2012;109(39):155535559. 26. Livak KJ. Allelic discrimination utilizing fluorogenic probes along with the five nuclease assay. Genet Anal. 1999;14(5):14349.mental illness. Lancet. 1990;336(8706):136. 11. Allen NC, et al. Systematic meta-analyses and field synopsis of genetic association research in schizophrenia: the SzGene database. Nat Genet. 2008; 40(7):82734. 12. Brandon NJ, Sawa A. Linking neurodevelopmental and synaptic theories of mental illness via DISC1. Nat Rev Neurosci. 2011;12(12):7072.Nevirapine 13.PMID:23910527 Cannon TD, et al. Association of DISC1/TRAX haplotypes with schizophrenia, decreased prefrontal gray matter, and impaired short- and long-term memory. Arch Gen Psychiatry. 2005;62(11):1205213. 14. Hikida T, et al. Dominant-negative DISC1 transgenic mice display schizophrenia-associated phenotypes detected by measures translatable to humans. Proc Natl Acad Sci U S A. 2007; 104(36):145014506. 15. Hariri AR, et al. Brain-derived neurotrophic element val66met polymorphism impacts human memory-related hippocampal activity and predicts memory functionality. J Neurosci. 2003; 23(17):6690694. 16. Bertolino A, et al. Prefrontal-hippocampal coupling throughout memory processing is modulated by COMT val158met genotype. Biol Psychiatry. 2006;60(11):1250258. 17. Genovese CR, Lazar NA, Nichols T. Thresholding of statistical maps in functional neuroimaging using the false discovery price. Neuroimage. 2002;15(four):87078. 18. Friston KJ, Buechel C, Fink GR, Morris J, Rolls E, Dolan RJ. Psychophysiological and modula-The Journal of Clinical Investigationhttp://www.jci.orgVolumeNumberJuly
Pathophysiology/ComplicationsO R I G I N A L A R T I C L ECerebral Blood Flow and Glucose Metabolism in Appetite-Related Brain Regions in Variety 1 Diabetic Individuals Just after Remedy With Insulin Detemir and NPH InsulinA randomized cont.
