Product Name :
Fudosteine
Description:
Fudosteine, also known as Cleanal and SS-320A, is a MUC5AC mucin hypersecretion inhibitor that is used as an expectorant in chronic bronchial inflammatory disorders.
CAS:
13189-98-5
Molecular Weight:
179.24
Formula:
C6H13NO3S
Chemical Name:
S-(3-hydroxypropyl)-L-cysteine
Smiles :
N[C@@H](CSCCCO)C(O)=O
InChiKey:
KINWYTAUPKOPCQ-YFKPBYRVSA-N
InChi :
InChI=1S/C6H13NO3S/c7-5(6(9)10)4-11-3-1-2-8/h5,8H,1-4,7H2,(H,9,10)/t5-/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Fudosteine, also known as Cleanal and SS-320A, is a MUC5AC mucin hypersecretion inhibitor that is used as an expectorant in chronic bronchial inflammatory disorders.|Product information|CAS Number: 13189-98-5|Molecular Weight: 179.24|Formula: C6H13NO3S|Synonym:|SS-320A|SS 320A|SS320A|Cleanal|Spelear|Chemical Name: S-(3-hydroxypropyl)-L-cysteine|Smiles: N[C@@H](CSCCCO)C(O)=O|InChiKey: KINWYTAUPKOPCQ-YFKPBYRVSA-N|InChi: InChI=1S/C6H13NO3S/c7-5(6(9)10)4-11-3-1-2-8/h5,8H,1-4,7H2,(H,9,10)/t5-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO: Insoluble. Water: 36 mg/mL(200.84 mM).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Fudosteine (FDS), a unique mucolytic antioxidant, shows a stronger scavenging effect of Peroxynitrite than N-acetyl-cysteine on DCDHF oxidation in vitro and in sputum macrophages, and also on Peroxynitrite-induced BSA nitration.{{Ustekinumab} web|{Ustekinumab} Immunology/Inflammation|{Ustekinumab} Biological Activity|{Ustekinumab} Data Sheet|{Ustekinumab} supplier|{Ustekinumab} Autophagy} Fudosteine (0.{{Biocytin} medchemexpress|{Biocytin} Metabolic Enzyme/Protease|{Biocytin} Immunology/Inflammation|{Biocytin} Technical Information|{Biocytin} References|{Biocytin} manufacturer} 1 mM) reduces Peroxynitrite-enhanced interleukin (IL)-1beta-induced IL-8 release and restores corticosteroid sensitivity defected by Peroxynitrite more potently than those induced by H(2)O(2) in A549 airway epithelial cells.PMID:23341580 Fudosteine significantly inhibits increases in GRO/CINC-1 at 10-100 mg/kg, and neutrophils and goblet cells at 30 and 100 mg/kg. Fudosteine inhibits goblet cell hyperplasia by inhibiting GRO/CINC-1 production and/or neutrophil migration. Fudosteine treatment reduces the expression levels of p-p38 MAPK and p-ERK in vivo and of p-ERK in vitro. Fudosteine inhibits MUC5AC mucin hypersecretion by reducing MUC5AC gene expression and the effects of fudosteine are associated with the inhibition of extracellular signal-related kinase and p38 mitogen-activated protein kinase in vivo and extracellular signal-related kinase in vitro. Fudosteine significantly suppresses blood flow of tracheal microvasculature increased by SO(2) exposure. Fudosteine scavenges superoxide anion generated from rat neutrophils, and enzymatically generated from xanthine oxidase-acetaldehyde reaction.|In Vivo:|Fudosteine (500 mg/kg, p.o.) significantly increases the amount of dye excreted into the respiratory tract. Fudosteine increases chloride ion concentration in broncho-alveolar lavage of rats.|References:|Rhee CK, et al. Eur Respir J, 2008, 32(5), 1195-1202.Komatsu H, et al. Pulm Pharmacol Ther, 2005, 18(2), 121-127.Osoata GO, et al. Chest, 2009, 135(6), 1513-1520.Products are for research use only. Not for human use.|
