Product Name :
PF-04929113 free base
Description:
PF-04929113, also known as SNX-5422; is a synthetic prodrug targeting the human heat-shock protein 90 (Hsp90) with potential antineoplastic activity. Although the mechanism of action remains to be fully elucidated, Hsp90 inhibitor SNX-5542 is rapidly converted to SNX-2112, which accumulates in tumors relative to normal tissues. SNX-2112 inhibits Hsp90, which may result in the proteasomal degradation of oncogenic client proteins, including HER2/ERBB2, and the inhibition of tumor cell proliferation.
CAS:
908115-27-5
Molecular Weight:
521.53
Formula:
C25H30F3N5O4
Chemical Name:
(1r, 4r)-4-((2-carbamoyl-5-(6, 6-dimethyl-4-oxo-3-(trifluoromethyl)-4, 5, 6, 7-tetrahydro-1H-indazol-1-yl)phenyl)amino)cyclohexyl glycinate
Smiles :
CC1(C)CC(=O)C2C(=NN(C3=CC(N[C@@H]4CC[C@H](CC4)OC(=O)CN)=C(C=C3)C(N)=O)C=2C1)C(F)(F)F
InChiKey:
AVDSOVJPJZVBTC-CTYIDZIISA-N
InChi :
InChI=1S/C25H30F3N5O4/c1-24(2)10-18-21(19(34)11-24)22(25(26,27)28)32-33(18)14-5-8-16(23(30)36)17(9-14)31-13-3-6-15(7-4-13)37-20(35)12-29/h5,8-9,13,15,31H,3-4,6-7,10-12,29H2,1-2H3,(H2,30,36)/t13-,15-
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
PF-04929113, also known as SNX-5422; is a synthetic prodrug targeting the human heat-shock protein 90 (Hsp90) with potential antineoplastic activity.{{Finerenone} medchemexpress|{Finerenone} Mineralocorticoid Receptor|{Finerenone} Purity & Documentation|{Finerenone} In Vitro|{Finerenone} custom synthesis|{Finerenone} Epigenetic Reader Domain} Although the mechanism of action remains to be fully elucidated, Hsp90 inhibitor SNX-5542 is rapidly converted to SNX-2112, which accumulates in tumors relative to normal tissues.{{Tofisopam} web|{Tofisopam} Protocol|{Tofisopam} Formula|{Tofisopam} custom synthesis|{Tofisopam} Autophagy} SNX-2112 inhibits Hsp90, which may result in the proteasomal degradation of oncogenic client proteins, including HER2/ERBB2, and the inhibition of tumor cell proliferation.PMID:23789847 |Product information|CAS Number: 908115-27-5|Molecular Weight: 521.53|Formula: C25H30F3N5O4|Synonym:|PF-4929113|SNX-5422|Related CAS Number:|1173111-67-5 (PF-04929113 mesylate)|Chemical Name: (1r, 4r)-4-((2-carbamoyl-5-(6, 6-dimethyl-4-oxo-3-(trifluoromethyl)-4, 5, 6, 7-tetrahydro-1H-indazol-1-yl)phenyl)amino)cyclohexyl glycinate|Smiles: CC1(C)CC(=O)C2C(=NN(C3=CC(N[C@@H]4CC[C@H](CC4)OC(=O)CN)=C(C=C3)C(N)=O)C=2C1)C(F)(F)F|InChiKey: AVDSOVJPJZVBTC-CTYIDZIISA-N|InChi: InChI=1S/C25H30F3N5O4/c1-24(2)10-18-21(19(34)11-24)22(25(26,27)28)32-33(18)14-5-8-16(23(30)36)17(9-14)31-13-3-6-15(7-4-13)37-20(35)12-29/h5,8-9,13,15,31H,3-4,6-7,10-12,29H2,1-2H3,(H2,30,36)/t13-,15-|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Soluble in DMSO|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|
