Product Name :
TL 13-110
Description:
TL13-110 is a negative control for TL13-112 (HY-123919) and a potent ALK inhibitor with an IC50 of 0.34 nM. TL13-110 does not degrade ALK in cells[1].
CAS:
2229037-09-4
Molecular Weight:
988.59
Formula:
C49H62ClN9O9S
Chemical Name:
N-(2-{2-[2-(4-{4-[(5-chloro-4-{[2-(propane-2-sulfonyl)phenyl]amino}pyrimidin-2-yl)amino]-2-methyl-5-(propan-2-yloxy)phenyl}piperidin-1-yl)ethoxy]ethoxy}ethyl)-2-{[1, 3-dioxo-2-(2-oxopiperidin-3-yl)-2, 3-dihydro-1H-isoindol-4-yl]amino}acetamide
Smiles :
CC1=CC(NC2=NC(NC3=CC=CC=C3S(=O)(=O)C(C)C)=C(Cl)C=N2)=C(C=C1C1CCN(CC1)CCOCCOCCNC(=O)CNC1=CC=CC2=C1C(=O)N(C1CCCNC1=O)C2=O)OC(C)C
InChiKey:
IJAANTOEOXWPKC-UHFFFAOYSA-N
InChi :
InChI=1S/C49H62ClN9O9S/c1-30(2)68-41-27-35(32(5)26-39(41)56-49-54-28-36(50)45(57-49)55-37-11-6-7-14-42(37)69(64,65)31(3)4)33-15-19-58(20-16-33)21-23-67-25-24-66-22-18-51-43(60)29-53-38-12-8-10-34-44(38)48(63)59(47(34)62)40-13-9-17-52-46(40)61/h6-8,10-12,14,26-28,30-31,33,40,53H,9,13,15-25,29H2,1-5H3,(H,51,60)(H,52,61)(H2,54,55,56,57)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
TL13-110 is a negative control for TL13-112 (HY-123919) and a potent ALK inhibitor with an IC50 of 0.34 nM. TL13-110 does not degrade ALK in cells[1].|Product information|CAS Number: 2229037-09-4|Molecular Weight: 988.{{Ambrisentan} web|{Ambrisentan} Endothelin Receptor|{Ambrisentan} Purity & Documentation|{Ambrisentan} In stock|{Ambrisentan} manufacturer|{Ambrisentan} Cancer} 59|Formula: C49H62ClN9O9S|Chemical Name: N-(2-{2-[2-(4-{4-[(5-chloro-4-{[2-(propane-2-sulfonyl)phenyl]amino}pyrimidin-2-yl)amino]-2-methyl-5-(propan-2-yloxy)phenyl}piperidin-1-yl)ethoxy]ethoxy}ethyl)-2-{[1, 3-dioxo-2-(2-oxopiperidin-3-yl)-2, 3-dihydro-1H-isoindol-4-yl]amino}acetamide|Smiles: CC1=CC(NC2=NC(NC3=CC=CC=C3S(=O)(=O)C(C)C)=C(Cl)C=N2)=C(C=C1C1CCN(CC1)CCOCCOCCNC(=O)CNC1=CC=CC2=C1C(=O)N(C1CCCNC1=O)C2=O)OC(C)C|InChiKey: IJAANTOEOXWPKC-UHFFFAOYSA-N|InChi: InChI=1S/C49H62ClN9O9S/c1-30(2)68-41-27-35(32(5)26-39(41)56-49-54-28-36(50)45(57-49)55-37-11-6-7-14-42(37)69(64,65)31(3)4)33-15-19-58(20-16-33)21-23-67-25-24-66-22-18-51-43(60)29-53-38-12-8-10-34-44(38)48(63)59(47(34)62)40-13-9-17-52-46(40)61/h6-8,10-12,14,26-28,30-31,33,40,53H,9,13,15-25,29H2,1-5H3,(H,51,60)(H,52,61)(H2,54,55,56,57)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO: 49.{{Tafamidis} site|{Tafamidis} Neuronal Signaling|{Tafamidis} Protocol|{Tafamidis} Data Sheet|{Tafamidis} manufacturer|{Tafamidis} Autophagy} 43 mg/mL(50 mM).PMID:23310954 |Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|TL13-110 also prompts the degradation of additional kinases including Aurora A, FER, PTK2 and RPS6KA1 with IC50 values of 9080 nM, 23.1 nM, 21.2 nM, and 480 nM, respectively.|References:|Chelsea E Powell, et al. Chemically Induced Degradation of Anaplastic Lymphoma Kinase (ALK). J Med Chem. 2018 May 10;61(9):4249-4255.Products are for research use only. Not for human use.|
