Product Name :
β-Nicotyrine
Description:
β-Nicotyrine is an alkaloid metabolite of nicotine as well as a major product of its pyrolysis., It binds comparably to two cytochrome P450 (CYP) isoforms, CYP2A6 and CYP2A13 (Kis = 7.5 and 5.6 µM, respectively), which are prominently involved in the metabolism of xenobiotics in the airways. However, β-nicotyrine appears to more effectively inactivate CYP2A6, leaving only 49% activity after a 10 minute exposure with 20 µM β-nicotyrine, as opposed to 87% remaining activity for CYP2A13 treated identically. Presumably through this effect, β-nicotyrine inhibits DNA strand breaks induced by the genotoxic tobacco metabolite (4-(methylnitrosamino)-1-(2-pyridyl)-1-butanone), which is bioactivated by CYP2A isoforms.
CAS:
487-19-4
Molecular Weight:
158.20
Formula:
C10H10N2
Chemical Name:
3-(1-methyl-1H-pyrrol-2-yl)pyridine
Smiles :
CN1C=CC=C1C1C=NC=CC=1
InChiKey:
RYFOJXFXERAMLS-UHFFFAOYSA-N
InChi :
InChI=1S/C10H10N2/c1-12-7-3-5-10(12)9-4-2-6-11-8-9/h2-8H,1H3
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
β-Nicotyrine is an alkaloid metabolite of nicotine as well as a major product of its pyrolysis.{{Prednisolone} site|{Prednisolone} Glucocorticoid Receptor|{Prednisolone} Biological Activity|{Prednisolone} In Vivo|{Prednisolone} custom synthesis|{Prednisolone} Epigenetics} , It binds comparably to two cytochrome P450 (CYP) isoforms, CYP2A6 and CYP2A13 (Kis = 7.{{Povorcitinib} site|{Povorcitinib} JAK/STAT Signaling|{Povorcitinib} Technical Information|{Povorcitinib} Formula|{Povorcitinib} custom synthesis|{Povorcitinib} Epigenetic Reader Domain} 5 and 5.PMID:35850484 6 µM, respectively), which are prominently involved in the metabolism of xenobiotics in the airways. However, β-nicotyrine appears to more effectively inactivate CYP2A6, leaving only 49% activity after a 10 minute exposure with 20 µM β-nicotyrine, as opposed to 87% remaining activity for CYP2A13 treated identically. Presumably through this effect, β-nicotyrine inhibits DNA strand breaks induced by the genotoxic tobacco metabolite (4-(methylnitrosamino)-1-(2-pyridyl)-1-butanone), which is bioactivated by CYP2A isoforms.|Product information|CAS Number: 487-19-4|Molecular Weight: 158.20|Formula: C10H10N2|Chemical Name: 3-(1-methyl-1H-pyrrol-2-yl)pyridine|Smiles: CN1C=CC=C1C1C=NC=CC=1|InChiKey: RYFOJXFXERAMLS-UHFFFAOYSA-N|InChi: InChI=1S/C10H10N2/c1-12-7-3-5-10(12)9-4-2-6-11-8-9/h2-8H,1H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|
