Al model with the best fit according to Akaike’s information criterion (AIC). Finally, we calculated the risk ratio and 95 confidence interval for death in relation to malnutrition.Ethics StatementThe research protocol was approved by the Institutional Review Boards of Hospital Couto Maia and the School of Nutrition, Federal University of Bahia, both in Salvador, Brazil. All participants or their legal representative (first degree relative or spouse) in the case of cognitive impairment agreed to participation in this research by signing a written informed consent. The data were analyzed anonymously.HIV-related hospitalization (median 2 [IQR 2?] prior hospitalizations) and 58 (68 ) reported current or prior HAART use (Table 1). Among HAART users, 41 (71 ) reported an interruption in therapy within the 6 months prior to hospitalization. The CD4 cell count was lower than 200 cells/mm3 for 73 of the 100 patients with available CD4 results (median 104 [IQR: 43?215] cells/mm3, Table 1) and HIV loads were generally high (median log10 viral load 4.92 [IQR 4.00?.33]). Nonetheless, patients who had previously used HAART presented with higher CD4 counts (median of 160 cells/mm3 for HAART users vs. 83 cells/mm3 for never users; Acetovanillone web Wilcoxon P = 0.03) and lower log10 HIV load (median of 4.51 log10 copies/mL for HAART users vs. 5.07 log10 copies/mL for never users; Wilcoxon P = 0.003). These findings were maintained when excluding patients informed of their HIV disease at this hospitalization (data not shown). The most frequent medical conditions associated with hospitalization included K162 biological activity oroesophageal candidiasis (61 patients, 48 ), chronic diarrhea (.30 days) (52, 41 ), pulmonary tuberculosis (34, 27 ), neurotoxoplasmosis (25, 20 ), meningitis (17, 13 ), pneumonia (17, 13 ) and extrapulmonary tuberculosis (14, 11 ), and a majority (68, 53 ) had multiple medical 23727046 conditions leading to hospitalization. Among patients with multiple diagnoses at admission, oroesophageal candidiasis (49, 72 ) and diarrhea (38, 56 ) were most frequently identified. Participants were hospitalized for a median duration of 16 days [IQR 9?4] (Table 1). Of the 127 patients we enrolled, nine were transferred to another hospital and clinical outcomes could not be evaluated. For the remaining 118 patients, 14 (12 ) required intensive care and 19 (16 ) died during hospitalization (Table 1).Nutritional StatusWe performed the nutritional evaluation within 72 hours of hospital admission for the majority (104 patients, 82 ) of those enrolled. Table 2 shows that nutritional characteristics were similar between patients who had height and weight estimated due to bed restriction (29, 23 ) and those who underwent direct measurement (98, 77 ). For the 102 patients who recalled their six months prior hospitalization weight, 44 (35 ) presented a weight loss greater than 20 and 70 (55 ) presented a weight loss greater than 10 . Overall, malnutrition (BMI,18.5 kg/m2) was found in 55 (43 ) of the patients and severe malnutrition (BMI ,16 kg/m2) in 19 (15 ). Lean body mass and fat body mass were 1527786 lower than the 5th percentile of a reference population for 80 (63 ) and 38 (30 ) patients, respectively. A majority of the patients had anemia (median hemoglobin 10.2; IQR 9.1?12.0 mg/dL) and hypoalbumenemia (median 2.4; IQR 1.8?2.9 g/dL).Results Patient RecruitmentDuring the ten-month study period, 185 unique patients were hospitalized with AIDS at the study hospital. Of these, 31 were not eligible for enr.Al model with the best fit according to Akaike’s information criterion (AIC). Finally, we calculated the risk ratio and 95 confidence interval for death in relation to malnutrition.Ethics StatementThe research protocol was approved by the Institutional Review Boards of Hospital Couto Maia and the School of Nutrition, Federal University of Bahia, both in Salvador, Brazil. All participants or their legal representative (first degree relative or spouse) in the case of cognitive impairment agreed to participation in this research by signing a written informed consent. The data were analyzed anonymously.HIV-related hospitalization (median 2 [IQR 2?] prior hospitalizations) and 58 (68 ) reported current or prior HAART use (Table 1). Among HAART users, 41 (71 ) reported an interruption in therapy within the 6 months prior to hospitalization. The CD4 cell count was lower than 200 cells/mm3 for 73 of the 100 patients with available CD4 results (median 104 [IQR: 43?215] cells/mm3, Table 1) and HIV loads were generally high (median log10 viral load 4.92 [IQR 4.00?.33]). Nonetheless, patients who had previously used HAART presented with higher CD4 counts (median of 160 cells/mm3 for HAART users vs. 83 cells/mm3 for never users; Wilcoxon P = 0.03) and lower log10 HIV load (median of 4.51 log10 copies/mL for HAART users vs. 5.07 log10 copies/mL for never users; Wilcoxon P = 0.003). These findings were maintained when excluding patients informed of their HIV disease at this hospitalization (data not shown). The most frequent medical conditions associated with hospitalization included oroesophageal candidiasis (61 patients, 48 ), chronic diarrhea (.30 days) (52, 41 ), pulmonary tuberculosis (34, 27 ), neurotoxoplasmosis (25, 20 ), meningitis (17, 13 ), pneumonia (17, 13 ) and extrapulmonary tuberculosis (14, 11 ), and a majority (68, 53 ) had multiple medical 23727046 conditions leading to hospitalization. Among patients with multiple diagnoses at admission, oroesophageal candidiasis (49, 72 ) and diarrhea (38, 56 ) were most frequently identified. Participants were hospitalized for a median duration of 16 days [IQR 9?4] (Table 1). Of the 127 patients we enrolled, nine were transferred to another hospital and clinical outcomes could not be evaluated. For the remaining 118 patients, 14 (12 ) required intensive care and 19 (16 ) died during hospitalization (Table 1).Nutritional StatusWe performed the nutritional evaluation within 72 hours of hospital admission for the majority (104 patients, 82 ) of those enrolled. Table 2 shows that nutritional characteristics were similar between patients who had height and weight estimated due to bed restriction (29, 23 ) and those who underwent direct measurement (98, 77 ). For the 102 patients who recalled their six months prior hospitalization weight, 44 (35 ) presented a weight loss greater than 20 and 70 (55 ) presented a weight loss greater than 10 . Overall, malnutrition (BMI,18.5 kg/m2) was found in 55 (43 ) of the patients and severe malnutrition (BMI ,16 kg/m2) in 19 (15 ). Lean body mass and fat body mass were 1527786 lower than the 5th percentile of a reference population for 80 (63 ) and 38 (30 ) patients, respectively. A majority of the patients had anemia (median hemoglobin 10.2; IQR 9.1?12.0 mg/dL) and hypoalbumenemia (median 2.4; IQR 1.8?2.9 g/dL).Results Patient RecruitmentDuring the ten-month study period, 185 unique patients were hospitalized with AIDS at the study hospital. Of these, 31 were not eligible for enr.
